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. 1997 Feb;60(2):313–319.

Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population.

L S Friedman 1, S A Gayther 1, T Kurosaki 1, D Gordon 1, B Noble 1, G Casey 1, B A Ponder 1, H Anton-Culver 1
PMCID: PMC1712407  PMID: 9012404

Abstract

A population-based series of 54 male breast cancer cases from Southern California were analyzed for germ-line mutations in the inherited breast/ovarian cancer genes, BRCA1 and BRCA2. Nine (17%) of the patients had a family history of breast and/or ovarian cancer in at least one first-degree relative. A further seven (13%) of the patients reported breast/ovarian cancer in at least one second-degree relative and in no first-degree relatives. No germ-line BRCA1 mutations were found. Two male breast cancer patients (4% of the total) were found to carry novel truncating mutations in the BRCA2 gene. Only one of the two male breast cancer patients carrying a BRCA2 mutation had a family history of cancer, with one case of ovarian cancer in a first-degree relative. The remaining eight cases (89%) of male breast cancer with a family history of breast/ovarian cancer in first-degree relatives remain unaccounted for by mutations in either the BRCA1 gene or the BRCA2 gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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