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. 1997 May;60(5):1174–1183.

Genetic relationships of Asians and Northern Europeans, revealed by Y-chromosomal DNA analysis.

T Zerjal 1, B Dashnyam 1, A Pandya 1, M Kayser 1, L Roewer 1, F R Santos 1, W Schiefenhövel 1, N Fretwell 1, M A Jobling 1, S Harihara 1, K Shimizu 1, D Semjidmaa 1, A Sajantila 1, P Salo 1, M H Crawford 1, E K Ginter 1, O V Evgrafov 1, C Tyler-Smith 1
PMCID: PMC1712423  PMID: 9150165

Abstract

We have identified a new T-->C transition on the human Y chromosome. C-allele chromosomes have been found only in a subset of the populations from Asia and northern Europe and reach their highest frequencies in Yakut, Buryats, and Finns. Examination of the microsatellite haplotypes of the C-allele chromosomes suggests that the mutation occurred recently in Asia. The Y chromosome thus provides both information about population relationships in Asia and evidence for a substantial paternal genetic contribution of Asians to northern European populations such as the Finns.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cooper G., Amos W., Hoffman D., Rubinsztein D. C. Network analysis of human Y microsatellite haplotypes. Hum Mol Genet. 1996 Nov;5(11):1759–1766. doi: 10.1093/hmg/5.11.1759. [DOI] [PubMed] [Google Scholar]
  2. Goldstein D. B., Zhivotovsky L. A., Nayar K., Linares A. R., Cavalli-Sforza L. L., Feldman M. W. Statistical properties of the variation at linked microsatellite loci: implications for the history of human Y chromosomes. Mol Biol Evol. 1996 Nov;13(9):1213–1218. doi: 10.1093/oxfordjournals.molbev.a025686. [DOI] [PubMed] [Google Scholar]
  3. Hammer M. F. A recent common ancestry for human Y chromosomes. Nature. 1995 Nov 23;378(6555):376–378. doi: 10.1038/378376a0. [DOI] [PubMed] [Google Scholar]
  4. Hammer M. F., Horai S. Y chromosomal DNA variation and the peopling of Japan. Am J Hum Genet. 1995 Apr;56(4):951–962. [PMC free article] [PubMed] [Google Scholar]
  5. Jobling M. A., Samara V., Pandya A., Fretwell N., Bernasconi B., Mitchell R. J., Gerelsaikhan T., Dashnyam B., Sajantila A., Salo P. J. Recurrent duplication and deletion polymorphisms on the long arm of the Y chromosome in normal males. Hum Mol Genet. 1996 Nov;5(11):1767–1775. doi: 10.1093/hmg/5.11.1767. [DOI] [PubMed] [Google Scholar]
  6. Jobling M. A., Tyler-Smith C. Fathers and sons: the Y chromosome and human evolution. Trends Genet. 1995 Nov;11(11):449–456. doi: 10.1016/s0168-9525(00)89144-1. [DOI] [PubMed] [Google Scholar]
  7. Kolman C. J., Sambuughin N., Bermingham E. Mitochondrial DNA analysis of Mongolian populations and implications for the origin of New World founders. Genetics. 1996 Apr;142(4):1321–1334. doi: 10.1093/genetics/142.4.1321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lahermo P., Sajantila A., Sistonen P., Lukka M., Aula P., Peltonen L., Savontaus M. L. The genetic relationship between the Finns and the Finnish Saami (Lapps): analysis of nuclear DNA and mtDNA. Am J Hum Genet. 1996 Jun;58(6):1309–1322. [PMC free article] [PubMed] [Google Scholar]
  9. Mathias N., Bayés M., Tyler-Smith C. Highly informative compound haplotypes for the human Y chromosome. Hum Mol Genet. 1994 Jan;3(1):115–123. doi: 10.1093/hmg/3.1.115. [DOI] [PubMed] [Google Scholar]
  10. Nevanlinna H. R. Genetic markers in Finland. Haematologia (Budap) 1980;13(1-4):65–74. [PubMed] [Google Scholar]
  11. Novoradovsky A. G., Spitsyn V. A., Duggirala R., Crawford M. H. Population genetics and structure of Buryats from the Lake Baikal Region of Siberia. Hum Biol. 1993 Oct;65(5):689–710. [PubMed] [Google Scholar]
  12. Roewer L., Kayser M., Dieltjes P., Nagy M., Bakker E., Krawczak M., de Knijff P. Analysis of molecular variance (AMOVA) of Y-chromosome-specific microsatellites in two closely related human populations. Hum Mol Genet. 1996 Jul;5(7):1029–1033. doi: 10.1093/hmg/5.7.1029. [DOI] [PubMed] [Google Scholar]
  13. Sajantila A., Lahermo P., Anttinen T., Lukka M., Sistonen P., Savontaus M. L., Aula P., Beckman L., Tranebjaerg L., Gedde-Dahl T. Genes and languages in Europe: an analysis of mitochondrial lineages. Genome Res. 1995 Aug;5(1):42–52. doi: 10.1101/gr.5.1.42. [DOI] [PubMed] [Google Scholar]
  14. Sajantila A., Päbo S. Language replacement in Scandinavia. Nat Genet. 1995 Dec;11(4):359–360. doi: 10.1038/ng1295-359. [DOI] [PubMed] [Google Scholar]
  15. Santos F. R., Gerelsaikhan T., Munkhtuja B., Oyunsuren T., Epplen J. T., Pena S. D. Geographic differences in the allele frequencies of the human Y-linked tetranucleotide polymorphism DYS19. Hum Genet. 1996 Mar;97(3):309–313. doi: 10.1007/BF02185760. [DOI] [PubMed] [Google Scholar]
  16. Semino O., Passarino G., Brega A., Fellous M., Santachiara-Benerecetti A. S. A view of the neolithic demic diffusion in Europe through two Y chromosome-specific markers. Am J Hum Genet. 1996 Oct;59(4):964–968. [PMC free article] [PubMed] [Google Scholar]
  17. Tyler-Smith C., Oakey R. J., Larin Z., Fisher R. B., Crocker M., Affara N. A., Ferguson-Smith M. A., Muenke M., Zuffardi O., Jobling M. A. Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes. Nat Genet. 1993 Dec;5(4):368–375. doi: 10.1038/ng1293-368. [DOI] [PubMed] [Google Scholar]
  18. Weber J. L., Wong C. Mutation of human short tandem repeats. Hum Mol Genet. 1993 Aug;2(8):1123–1128. doi: 10.1093/hmg/2.8.1123. [DOI] [PubMed] [Google Scholar]
  19. Whitfield L. S., Sulston J. E., Goodfellow P. N. Sequence variation of the human Y chromosome. Nature. 1995 Nov 23;378(6555):379–380. doi: 10.1038/378379a0. [DOI] [PubMed] [Google Scholar]
  20. de la Chapelle A. Disease gene mapping in isolated human populations: the example of Finland. J Med Genet. 1993 Oct;30(10):857–865. doi: 10.1136/jmg.30.10.857. [DOI] [PMC free article] [PubMed] [Google Scholar]

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