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. 1997 May;60(5):1168–1173.

A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24.

K Verhoeven 1, G Van Camp 1, P J Govaerts 1, W Balemans 1, I Schatteman 1, M Verstreken 1, L Van Laer 1, R J Smith 1, M R Brown 1, P H Van de Heyning 1, T Somers 1, F E Offeciers 1, P J Willems 1
PMCID: PMC1712440  PMID: 9150164

Abstract

We performed linkage analysis in a Belgian family with autosomal dominant midfrequency hearing loss, which has a prelingual onset and a nonprogressive course in most patients. We found LOD scores >6 with markers on chromosome 11q. Analysis of key recombinants maps this deafness gene (DFNA12) to a 36-cM interval on chromosome 11q22-24, between markers D11S4120 and D11S912. The critical regions for the recessive deafness locus DFNB2 and the dominant locus DFNA11, which were previously localized to the long arm of chromosome 11, do not overlap with the candidate interval of DFNA12.

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Selected References

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