Abstract
The cell surface of peripheral lymphocytes from a patient with chronic lymphocytic leukaemia reacted strongly with fluorescein conjugated anti-IgM and kappa serum. Moreover in the presence of complement anti-IgM serum was cytotoxic. This patient was unusually resistant to various therapeutic measures. Serum immunoglobulin levels were slightly subnormal. The reactivity described differs from other chronic lymphocytic leukaemias studied but could be found in a number of Burkitt cases. The leukaemia cells may represent the malignant transformation of a normal lymphoid cell specialized to carry immunoglobulin on its cell membrane.
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Selected References
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- Clifford P., Gripenberg U., Klein E., Fenyo E. M., Manolov G. Treatment of Burkitt's lymphoma. Lancet. 1968 Aug 31;2(7566):517–518. doi: 10.1016/s0140-6736(68)90681-8. [DOI] [PubMed] [Google Scholar]
- Klein E., Klein G., Nadkarni J. S., Nadkarni J. J., Wigzell H., Clifford P. Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines. Cancer Res. 1968 Jul;28(7):1300–1310. [PubMed] [Google Scholar]
- Strom R., Klein E. Fluorometric quantitation of fluorescein-coupled antibodies attached to the cell membrane. Proc Natl Acad Sci U S A. 1969 Aug;63(4):1157–1163. doi: 10.1073/pnas.63.4.1157. [DOI] [PMC free article] [PubMed] [Google Scholar]