Abstract
Mice infected at birth with Moloney virus were stimulated with an unrelated antigen (sheep red blood cells) during the lag period before the outbreak of leukaemia. Their spleen cell suspensions were incubated with anti-Moloney serum and complement before plating by the Jerne technique. This treatment—compared with incubation with normal serum and complement—caused a decrease in number of plaque forming cells in one-fourth of the infected mice, indicating that their antibody producing cells contained virus specific surface antigen.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BREYERE E. J., WILLIAMS L. B. ANTIGENS ASSOCIATED WITH A TUMOR VIRUS: REJECTION OF ISOGENIC SKIN GRAFTS FROM LEUKEMIC MICE. Science. 1964 Nov 20;146(3647):1055–1056. doi: 10.1126/science.146.3647.1055. [DOI] [PubMed] [Google Scholar]
- Celada F., Klein G. Autonomy of H-2 genes in individual immunocytes. Nature. 1967 Sep 9;215(5106):1136–1139. doi: 10.1038/2151136a0. [DOI] [PubMed] [Google Scholar]
- Cremer N. E., Taylor D. O., Lennette E. H. Localization of immunoglobulin and viral antigen in rats infected with Moloney virus. J Natl Cancer Inst. 1969 May;42(5):695–707. [PubMed] [Google Scholar]
- Klein E., Klein G. Antibody response and leukemia development in mice inoculated neonatally with the Moloney virus. Cancer Res. 1965 Jul;25(6):851–854. [PubMed] [Google Scholar]
- Klein G., Klein E., Haughton G. Variation of antigenic characteristics between different mouse lymphomas induced by the Moloney virus. J Natl Cancer Inst. 1966 Apr;36(4):607–621. doi: 10.1093/jnci/36.4.607. [DOI] [PubMed] [Google Scholar]
- Mathé G. Are the neoantigens induced by chemical carcinogens or by leukaemogenic viruses particular to cancer cells? Transplant Proc. 1969 Mar;1(1):113–118. [PubMed] [Google Scholar]
- STUECK B., OLD L. J., BOYSE E. A. ANTIGENIC CONVERSION OF ESTABLISHED LEUKEMIAS BY AN UNRELATED LEUKAEMOGENIC VIRUS. Nature. 1964 Jun 6;202:1016–1018. doi: 10.1038/2021016b0. [DOI] [PubMed] [Google Scholar]
- Svet-Moldavsky G. J., Mkheidze D. M., Liozner A. L. Two phenomena associated with skin grafting from tumor-bearing syngeneic donors. J Natl Cancer Inst. 1967 Jun;38(6):933–938. [PubMed] [Google Scholar]