Abstract
Peripheral blood lymphocytes from a patient with lung cancer were compared with those from his healthy identical twin for stimulation of DNA-synthesis upon exposure to mitomycin-C treated tumour cells, autochthonous, syngeneic and allogeneic lymphocytes, and phytohaemagglutinin in vitro. A `mixed leucocyte–target interaction test' showed DNA-synthesis in the syngeneic lymphocytes to be higher when mixed with mitomycin-C treated tumour cells than when mixed with lymphocytes from either twin. The results show a decreased ability to respond to phytohaemagglutinin and to the stimulus of allogeneic lymphocytes in the lymphocytes of the tumour-bearing individual as compared with those of his healthy twin.
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Selected References
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- BACH F., HIRSCHHORN K. LYMPHOCYTE INTERACTION: A POTENTIAL HISTOCOMPATIBILITY TEST IN VITRO. Science. 1964 Feb 21;143(3608):813–814. doi: 10.1126/science.143.3608.813. [DOI] [PubMed] [Google Scholar]
- Bach F. H., Voynow N. K. One-way stimulation in mixed leukocyte cultures. Science. 1966 Jul 29;153(3735):545–547. doi: 10.1126/science.153.3735.545. [DOI] [PubMed] [Google Scholar]
- HIRSCHHORN K., BACH F., RAPAPORT F. T., CONVERSE J. M., LAWRENCE H. S. THE RELATIONSHIP OF IN VITRO LYMPHOCYTE COMPATIBILITY TO HOMOGRAFT SENSITIVITY IN MAN. Ann N Y Acad Sci. 1964 Nov 30;120:303–306. doi: 10.1111/j.1749-6632.1964.tb34729.x. [DOI] [PubMed] [Google Scholar]
- Klein G. Tumor antigens. Annu Rev Microbiol. 1966;20:223–252. doi: 10.1146/annurev.mi.20.100166.001255. [DOI] [PubMed] [Google Scholar]
- OLD L. J., BOYSE E. A. IMMUNOLOGY OF EXPERIMENTAL TUMORS. Annu Rev Med. 1964;15:167–186. doi: 10.1146/annurev.me.15.020164.001123. [DOI] [PubMed] [Google Scholar]