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. 1970 Feb;6(2):263–272.

Interferon response of lymphocytes in disorders with decreased resistance to infections

H Strander, K Cantell, J Leisti, E Nikkila
PMCID: PMC1712774  PMID: 4314167

Abstract

Interferon production was induced by Sendai and Newcastle disease virus in blood obtained from patients with Down's syndrome (eight cases), Fanconi's anaemia (one case), subacute sclerosing panencephalitis (one case), blast cell leukaemia (nine cases), chronic lymphocytic leukaemia (six cases) and control subjects. The titres per millilitre of blood varied greatly, but the interferon response per lymphocyte was comparatively constant in all groups with the exception of chronic lymphocytic leukaemia, where the cells displayed a markedly reduced interferon-producing ability.

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Selected References

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  1. Burnet F. M. Measles as an index of immunological function. Lancet. 1968 Sep 14;2(7568):610–613. doi: 10.1016/s0140-6736(68)90701-0. [DOI] [PubMed] [Google Scholar]
  2. Cantell K., Strander H., Saxén L., Meyer B. Interferon response of human leukocytes during intrauterine and postnatal life. J Immunol. 1968 Jun;100(6):1304–1309. [PubMed] [Google Scholar]
  3. Chessin L. N., Glade P. R., Asofsky R., Baker P. D., Reisfeld R., Terry W. Studies on human peripheral blood lymphocytes in vitro. V. Biosynthesis of immunoglobulins. J Immunol. 1968 Sep;101(3):458–468. [PubMed] [Google Scholar]
  4. Edelman R., Wheelock E. F. Enhancement of replication of vesicular stomatitis virus in human lymphocyte cultures treated with heterologous anti-lymphocyte serum. Lancet. 1968 Apr 13;1(7546):771–775. doi: 10.1016/s0140-6736(68)92226-5. [DOI] [PubMed] [Google Scholar]
  5. GOOD R. A., KELLY W. D., ROTSTEIN J., VARCO R. L. Immunological deficiency diseases. Agammaglobulinemia, hypogammaglobulinemia, Hodgkin's disease and sarcoidosis. Prog Allergy. 1962;6:187–319. [PubMed] [Google Scholar]
  6. GRESSER I. Production of interferon by suspensions of human leucocytes. Proc Soc Exp Biol Med. 1961 Dec;108:799–803. doi: 10.3181/00379727-108-27072. [DOI] [PubMed] [Google Scholar]
  7. Hadházy G., Gergely L., Nagy G., Tóth F. D. Comparison of interferon production in vitro by leukocytes from healthy and polycythaemic persons. Acta Microbiol Acad Sci Hung. 1968;15(2):141–144. [PubMed] [Google Scholar]
  8. Hadházy G., Gergely L., Tóth F. D., Szegedi G. Comparative study on the interferon production by the leukocytes of healthy and leukaemic subjects. Acta Microbiol Acad Sci Hung. 1967;14(4):391–397. [PubMed] [Google Scholar]
  9. Hirsch M. S., Murphy F. A. Effects of anti-lymphoid sera on viral infections. Lancet. 1968 Jul 6;2(7558):37–40. doi: 10.1016/s0140-6736(68)92904-8. [DOI] [PubMed] [Google Scholar]
  10. Hirsch M. S., Murphy F. A., Hicklin M. D. Immunopathology of lymphocytic choriomeningitis viurs infection of newborn mice. Antithymocyte serum effects on glomerulonephritis and wasting disease. J Exp Med. 1968 Apr 1;127(4):757–766. doi: 10.1084/jem.127.4.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LEE S. H., OZERE R. L. PRODUCTION OF INTERFERON BY HUMAN MONONUCLEAR LEUCOCYTES. Proc Soc Exp Biol Med. 1965 Jan;118:190–195. doi: 10.3181/00379727-118-29794. [DOI] [PubMed] [Google Scholar]
  12. Lawrence H. S. In vitro correlates of delayed hypersensitivity. Introductory remarks. Fed Proc. 1968 Jan-Feb;27(1):3–5. [PubMed] [Google Scholar]
  13. MOORHEAD P. S., NOWELL P. C., MELLMAN W. J., BATTIPS D. M., HUNGERFORD D. A. Chromosome preparations of leukocytes cultured from human peripheral blood. Exp Cell Res. 1960 Sep;20:613–616. doi: 10.1016/0014-4827(60)90138-5. [DOI] [PubMed] [Google Scholar]
  14. Perry S., Irvin G. L., 3rd, Whang J. Studies of lymphocyte kinetics in man. Blood. 1967 Jan;29(1):22–28. [PubMed] [Google Scholar]
  15. Schmid W., Schärer K., Baumann T., Fanconi G. Chromosomenbrüchigkeit bei der familiären Panmyelopathie (Typus Fanconi) Schweiz Med Wochenschr. 1965 Oct 23;95(43):1461–1464. [PubMed] [Google Scholar]
  16. Strander H., Cantell K. Further studies on the production of interferon by human leukocyte in vitro. Ann Med Exp Biol Fenn. 1967;45(1):20–29. [PubMed] [Google Scholar]
  17. Strander H., Cantell K. Production of interferon by human leukocytes in vitro. Ann Med Exp Biol Fenn. 1966;44(2):265–273. [PubMed] [Google Scholar]
  18. Volkert M., Lundstedt C. The provocation of latent lymphocytic choriomeningitis virus infections in mice by treatment with antilymphocytic serum. J Exp Med. 1968 Feb 1;127(2):327–339. doi: 10.1084/jem.127.2.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wheelock E. F. Virus replication and high-titered interferon production in human leukocyte cultures inoculated with Newcastle disease virus. J Bacteriol. 1966 Nov;92(5):1415–1421. doi: 10.1128/jb.92.5.1415-1421.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. van Furth R., Schuit H. R., Hijmans W. The formation of immunoglobulins by human tissues in vitro. IV. Circulating lymphocytes in normal and pathological conditions. Immunology. 1966 Jul;11(1):29–40. [PMC free article] [PubMed] [Google Scholar]

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