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. 1970 Apr;6(4):587–595.

Endocrinological studies in ataxia-telangiectasia and other immunological deficiency diseases

A J Ammann, R J Duquesnoy, R A Good
PMCID: PMC1712790  PMID: 5477923

Abstract

Endocrinological and immunological studies were performed in five patients with ataxia-telangiectasia, two patients with sex-linked non-lymphopenic hypogammaglobulinaemia, one patient with sex-linked lymphopenic hypogammaglobulinaemia, and two patients with hypopituitary dwarfism. One of five patients with ataxia-telangiectasia had deficient growth hormone responses to insulin-induced hypoglycaemia but normal responses to arginine infusion. One pubertal ataxia-telangiectasia patient had increased gonadotropin secretion. Patients with hypopituitary dwarfism failed to respond to insulin-induced hypoglycaemia and arginine infusion with increased growth hormone secretion. The patients with sex-linked lymphopenic and non-lymphopenic hypogammaglobulinaemia had normal endocrine function. Immunological studies indicated defects in humoral and cellular immunity in the patients with ataxia-telangiectasia and sex-linked lymphopenic and non-lymphopenic hypogammaglobulinaemia, whereas normal immunological function was demonstrated in the patients with hypopituitary dwarfism. No relationship between endocrinological and immunological function could be demonstrated in these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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