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. 1970 Apr;6(4):619–625.

Nucleases in immunity. II. Ineffectiveness of oxogenous RNase on the antibody plaque response of immunized mice

A K Chakrabarty, H Friedman
PMCID: PMC1712802  PMID: 4920600

Abstract

The effect of bovine ribonuclease on the immune response of mice to sheep erythrocytes was studied. Mice were injected either with a polyribonuclease (poly-RNase) complex once before immunization, or with multiple daily injections of soluble RNase before and after immunization. The number of individual haemolysin-forming cells in the spleens of the animals was determined, as were the serum antibody titres to the erythrocytes. There was no evidence of an immunosuppressive effect in any of the treated animals, as compared to normal, non-treated controls, under conditions in which a marked immunosuppression had been noted in other studies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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