Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
letter
. 1970 Jun;6(6):969–974.

Normal lymphocyte transfer tests in leprosy

K Saha, M M Mittal
PMCID: PMC1712813  PMID: 5477731

Abstract

Lymphocyte transfer tests (intradermal inoculations of 2·5 million of allogenic lymphocytes) were done in five normal persons, five lepromatous leprosy and four tuberculoid leprosy patients. Observations were made daily for at least 10 days. In normal persons an initial reaction of moderate induration and erythema reached its maximum diameter between 24 and 48 hr and a secondary reaction occurred on the 3rd–5th day, reached its peak on the 6th–7th day and disappeared between the 10th and 13th day. In the lepromatous leprosy cases there was neither an initial nor a secondary reaction. In two of four cases of tuberculoid leprosy only an initial reaction was observed while in the other two cases the reaction appeared on the 4th day, reached its peak on the 6th day and persisted to the 13th day.

Full text

PDF
969

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AISENBERG A. C. STUDIES OF LYMPHOCYTE TRANSFER REACTIONS IN HODGKIN'S DISEASE. J Clin Invest. 1965 Apr;44:555–564. doi: 10.1172/JCI105168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. AMOS D. B., NICKS P. J., PEACOCKE N., SIEKER H. O. AN EVALUATION OF THE NORMAL LYMPHOCYTE TRANSFER TEST IN MAN. J Clin Invest. 1965 Feb;44:219–230. doi: 10.1172/JCI105136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BRENT L., MEDAWAR P. B. Tissue transplantation: a new approach to the "typing" problem. Br Med J. 1963 Aug 3;2(5352):269–272. doi: 10.1136/bmj.2.5352.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brent L., Medawar P. B. Cellular immunity and the homograft reaction. Br Med Bull. 1967 Jan;23(1):55–60. doi: 10.1093/oxfordjournals.bmb.a070517. [DOI] [PubMed] [Google Scholar]
  5. Dierks R. E., Shepard C. C. Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. Proc Soc Exp Biol Med. 1968 Feb;127(2):391–395. doi: 10.3181/00379727-127-32698. [DOI] [PubMed] [Google Scholar]
  6. GOLDSMITH K. L. DONOR SELECTION AND COMPATIBILITY TYPING. Br Med Bull. 1965 May;21:162–PASSIM. doi: 10.1093/oxfordjournals.bmb.a070386. [DOI] [PubMed] [Google Scholar]
  7. Hattler B. G., Jr, Amos D. B. Reactions obtained with transferred lymphocytes in patients with advanced cancer. J Natl Cancer Inst. 1965 Dec;35(6):927–935. [PubMed] [Google Scholar]
  8. Levin A. G., Miller D. G., Southam C. M. Lymphocyte transfer tests in cancer patients and healthy people. Cancer. 1968 Sep;22(3):500–506. doi: 10.1002/1097-0142(196809)22:3<500::aid-cncr2820220303>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  9. Lischner H. W., Dacou C., DiGeorge A. M. Normal lymphocyte transfer (NLT) test: negative response in a patient with congenital absence of the thymus. Transplantation. 1967 May;5(3):555–557. [PubMed] [Google Scholar]
  10. Möller E., Lapp W. Cytotoxic effects in vitro by lymphoid cells from specifically tolerant animals. Immunology. 1969 Apr;16(4):561–566. [PMC free article] [PubMed] [Google Scholar]
  11. Turk J. L., Waters M. F. Immunological basis for depression of cellular immunity and the delayed allergic response in patients with lepromatous leprosy. Lancet. 1968 Aug 24;2(7565):436–438. doi: 10.1016/s0140-6736(68)90472-8. [DOI] [PubMed] [Google Scholar]
  12. Waldorf D. S., Sheagren J. N., Trautman J. R., Block J. B. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. 1966 Oct 8;2(7467):773–776. doi: 10.1016/s0140-6736(66)90366-7. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES