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. 1970 Jun;6(6):963–968.

Tumour-distinctive cellular immunity to renal carcinoma

J Stjernswärd, L -E Almgård, S Franzén, T von Schreeb, L B Wadström
PMCID: PMC1712822  PMID: 5477730

Abstract

The possible existence of a cellbound tumour-distinctive immune response in patients with renal adenocarcinoma (hypernephroma) was studied. The peripheral lymphocytes of the patient were mixed in vitro with autochthonous malignant and non-malignant cells and allogeneic lymphocytes in which DNA-synthesis had been blocked by Mitomycine-C in a `Mixed Lymphocyte Target Interaction' test, MLTI-test. If the tumour cells possess something on their surface, e.g. tumour-specific antigens, making them foreign to the patient's non-malignant cells, the patient's own lymphocytes should be stimulated to increased DNA-synthesis by autochthonous tumour cells but not by autochthonous non-malignant cells. Peripheral lymphocytes from three out of the first six tested patients showed increased DNA-synthesis after contact with autochthonous renal carcinoma cells in vitro. These results indicate that tumor-distinctive immune reactions exist in patients with renal carcinoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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