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. 1970 Aug;7(2):133–137.

Sub-units of the first complement component in immunologic deficiency syndromes: independence of C1s and C1q

R M Stroud, K Nagaki, R J Pickering, H Gewurz, R A Good, M D Cooper
PMCID: PMC1712843  PMID: 4991118

Abstract

Normal concentrations of C1 esterase, C1s, have been found in nineteen individuals with a variety of immunologic deficiency syndromes. C1q levels are markedly low in patients with lymphopenic hypogammaglobulinaemia. The lack of correlation of serum concentrations of C1s with C1q in several patients suggests a separate mode of synthesis or catabolism for these C1 subunits. Furthermore, the extreme C1q deficiency in lymphopenic hypogammaglobulinaemic patients may play a role in their serious prognosis; however the normal C1s concentrations would allow some complement mediated functions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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