Abstract
Exocrine IgA in serum was estimated by a sensitive haemagglutination-inhibition technique using a specific anti-secretory piece antiserum and colostral IgA coated cells. The mean level in healthy individuals was 5·2 μg/ml. Decreased levels are found in cord sera and the sera of IgA deficient individuals. Normal levels were found in the sera of patients with renal disease and slightly elevated levels in the sera of a group of patients with neoplastic disease. Elevated levels were found in the sera of lactating women, patients with acute chest infection, and patients with sero-positive rheumatoid arthritis.
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- Butler W. T., Rossen R. D., Waldmann T. A. The mechanism of appearance of immunoglobulin A in nasal secretions in man. J Clin Invest. 1967 Dec;46(12):1883–1893. doi: 10.1172/JCI105678. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
- Hart F. D. Rheumatoid arthritis: extra-articular manifestations. Br Med J. 1969 Jul 19;3(5663):131–136. doi: 10.1136/bmj.3.5663.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Newcomb R. W., Normansell D., Stanworth D. R. A structural study of human exocrine IgA globulin. J Immunol. 1968 Nov;101(5):905–914. [PubMed] [Google Scholar]
- Rowe D. S., McGregor I. A., Smith S. J., Hall P., Williams K. Plasma immunoglobulin concentrations in a West African (Gambian) community and in a group of healthy British adults. Clin Exp Immunol. 1968 Jan;3(1):63–79. [PMC free article] [PubMed] [Google Scholar]
- Thompson R. A., Asquith P., Cooke W. T. Secretory IgA in the serum. Lancet. 1969 Sep 6;2(7619):517–519. doi: 10.1016/s0140-6736(69)90217-7. [DOI] [PubMed] [Google Scholar]
- Thompson R. A. Secretory piece linked to IgM in individuals deficient in IgA. Nature. 1970 Jun 6;226(5249):946–948. doi: 10.1038/226946a0. [DOI] [PubMed] [Google Scholar]
- Tourville D. R., Adler R. H., Bienenstock J., Tomasi T. B., Jr The human secretory immunoglobulin system: immunohistoligical localization of gamma A, secretory "piece," and lactoferrin in normal human tissues. J Exp Med. 1969 Feb 1;129(2):411–429. doi: 10.1084/jem.129.2.411. [DOI] [PMC free article] [PubMed] [Google Scholar]