Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1970 Dec;7(6):865–874.

An immunological basis for the anaemia of acute Salmonella gallinarum infection of chicken. I. Haematological changes and their association with in vivo modification of the erythrocytes

R Assoku, W Penhale, A Buxton
PMCID: PMC1712865  PMID: 5493530

Abstract

The haematological changes occurring during the course of acute Salmonella gallinarum infection of chicken have been investigated. A severe, acute anaemia, together with reticulocytosis and hepato-splenomegaly, were regularly observed. The findings indicated that these changes were due to increased extravascular destruction of erythrocytes rather than by inhibition of haemopoietic activity.

Coincidentally with the development of the anaemia, erythrocytes became regularly modified serologically in vivo, suggesting a possible relationship between these two phenomena. In contrast, in chickens which died of the per-acute form, where normal haematologic values were found, in vivo erythrocyte modification was not detected.

As the anaemia increased in severity, a change in the type and in vivo erythrocyte modification was also frequently noted.

It is considered that in vivo erythrocyte modification initiates the severe haematological changes observed and it is postulated that the underlying mechanism of increased erythrocyte destruction is immunological.

Full text

PDF
865

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Assoku R. K., Penhale W. J., Buxton A. Haematological changes in acute experimental Salmonella gallinarum infection in chickens. J Comp Pathol. 1970 Jul;80(3):473–485. doi: 10.1016/0021-9975(70)90080-0. [DOI] [PubMed] [Google Scholar]
  2. Assoku R., Penhale W. An immunological basis for the anaemia of acute Salmonella gallinarum infection of chicken. II. The relationship of the immune response to the development of the haemolytic anaemia. Clin Exp Immunol. 1970 Dec;7(6):875–883. [PMC free article] [PubMed] [Google Scholar]
  3. BOYDEN S. V. Fixation of bacterial products by erythrocytes in vivo and by Leucocytes. Nature. 1953 Feb 28;171(4348):402–403. doi: 10.1038/171402a0. [DOI] [PubMed] [Google Scholar]
  4. BROWN G. M. The pathogenesis of secondary anaemias. Can Med Assoc J. 1950 May;62(5):472–475. [PMC free article] [PubMed] [Google Scholar]
  5. BUXTON A. Pathological changes in the blood of chickens infected with Salmonella gallinarum. J Comp Pathol. 1960 Jul;70:308–325. doi: 10.1016/s0368-1742(60)80030-6. [DOI] [PubMed] [Google Scholar]
  6. BUXTON A. The in vivo sensitization of avian erythrocytes with Salmonella gallinarum polysaccharide. Immunology. 1959 Jul;2:203–210. [PMC free article] [PubMed] [Google Scholar]
  7. CARTWRIGHT G. E., WINTROBE M. M. The anemia of infection. XVII. A review. Adv Intern Med. 1952;5:165–226. [PubMed] [Google Scholar]
  8. CEPPELLINI R., DE GREGORIO M. Crisi emolitica in animali batterio-immuni trasfusi con sangue omologo sensibilizzato in vitro mediante l'antigene batterico specifico. Boll Ist Sieroter Milan. 1953 Nov-Dec;32(11-12):445–453. [PubMed] [Google Scholar]
  9. Cox H. W. A factor associated with anemia and immunity in Plasmodium knowlesi infections. Mil Med. 1966 Sep;131(9 Suppl):1195–1200. [PubMed] [Google Scholar]
  10. Croft J. D., Jr, Swisher S. N., Jr, Gilliland B. C., Bakemeier R. F., Leddy J. P., Weed R. I. Coombs'-test positivity induced by drugs. Mechanisms of immunologic reactions and red cell destruction. Ann Intern Med. 1968 Jan;68(1):176–187. doi: 10.7326/0003-4819-68-1-176. [DOI] [PubMed] [Google Scholar]
  11. Jacob H. S. A pathogenic classification of the anemias. Med Clin North Am. 1966 Nov;50(6):1679–1687. doi: 10.1016/s0025-7125(16)33113-3. [DOI] [PubMed] [Google Scholar]
  12. KOPPISCH E., OLIVER-GONZALEZ J. Agglutination of Erythrocytes in vivo in mice after injection of Ascaris extracts, related to immunization with human erythrocytes. Proc Soc Exp Biol Med. 1959 Apr;100(4):827–829. doi: 10.3181/00379727-100-24792. [DOI] [PubMed] [Google Scholar]
  13. MCFADZEAN A. J., CHOA G. H. Haemolytic anaemia in typhoid fever; a report of six cases, together with the effect of chloramphenicol and A.C.T.H. Br Med J. 1953 Aug 15;2(4832):360–366. doi: 10.1136/bmj.2.4832.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MOOLTEN S. E., CLARK E., GLASSER B. F., KATZ E., MILLER B. S. Blood stream invasion by Newcastle disease virus associated with hemolytic anemia and encephalopathy; report of three cases. Am J Med. 1953 Mar;14(3):294–306. doi: 10.1016/0002-9343(53)90041-2. [DOI] [PubMed] [Google Scholar]
  15. Mengel C. E., Metz E., Yancey W. S. Anemia during actue infections. Role of glucose-6-phosphate dehydrogenase deficiency in Negroes. Arch Intern Med. 1967 Mar;119(3):287–290. doi: 10.1001/archinte.119.3.287. [DOI] [PubMed] [Google Scholar]
  16. NETER E. Bacterial hemagglutination and hemolysis. Bacteriol Rev. 1956 Sep;20(3):166–188. doi: 10.1128/br.20.3.166-188.1956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. RETIEF F. P., HOFMEYR N. G. ACUTE HAEMOLYTIC ANAEMIA AS A COMPLICATION OF TYPHOID FEVER. S Afr Med J. 1965 Jan 30;39:96–97. [PubMed] [Google Scholar]
  18. RUGGIERI P. A. Hemolytic anemia in typhoid fever. Del Med J. 1961 Mar;33:77–80. [PubMed] [Google Scholar]
  19. SHAW A. B. Haemoglobinuria in typhoid fever; report of two cases. Lancet. 1951 Nov 3;2(6688):813–816. [PubMed] [Google Scholar]
  20. SHUMWAY C. N., BOKKENHEUSER V., POLLOCK D., NETER E. SURVIVAL IN IMMUNE AND NONIMMUNE RABBITS OF CR51-LABELED ERYTHROCYTES MODIFIED BY BACTERIAL ANTIGEN. J Lab Clin Med. 1963 Oct;62:600–607. [PubMed] [Google Scholar]
  21. ZUCKERMAN A. AUTOIMMUNIZATION AND OTHER TYPES OF INDIRECT DAMAGE TO HOST CELLS AS FACTORS IN CERTAIN PROTOZOAN DISEASES. Exp Parasitol. 1964 Apr;15:138–183. doi: 10.1016/0014-4894(64)90014-1. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES