Abstract
The influence of acute and chronic infection and hypergammaglobulinaemia on the titres of anti-globulin antibodies was studied in 128 patients. Very high titres of serum agglutinators were found to be associated with gram positive septicaemia. This infection had no influence on the titres of rheumatoid factors. Elevated titres of serum agglutinators may be helpful in differentiating `benign' from `malignant' gammopathy.
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Selected References
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- CATHCART E. S., WILLIAMS R. C., Jr, ROSS H., CALKINS E. The relationship of the latex fixation test to the clinical and serologic manifestations of leprosy. Am J Med. 1961 Nov;31:758–765. doi: 10.1016/0002-9343(61)90160-7. [DOI] [PubMed] [Google Scholar]
- GOODMAN J. W. Reaction of rheumatoid sera with fragments of papain-digested rabbit gamma globulin. Proc Soc Exp Biol Med. 1961 Apr;106:822–825. doi: 10.3181/00379727-106-26488. [DOI] [PubMed] [Google Scholar]
- HARBOE M., RAU B., AHO K. PROPERTIES OF VARIOUS ANTI-GAMMA-GLOBULIN FACTORS IN HUMAN SERA. J Exp Med. 1965 Apr 1;121:503–519. doi: 10.1084/jem.121.4.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kormeier L. C., Ing J. T., Mandy W. J. Specificity of antiglobulin factors in normal human serum reacting with enzyme digested gamma-G-globulin. J Immunol. 1968 Mar;100(3):612–621. [PubMed] [Google Scholar]
- Natvig J. B. Heterogeneity of anti-gamma-globulin factors detected by pepsin-digested human gamma G-globulin. Acta Pathol Microbiol Scand. 1966;66(3):369–382. doi: 10.1111/apm.1966.66.3.369. [DOI] [PubMed] [Google Scholar]
- Natvig J. B. Reaction of human anti-antibodies with incomplete anti-D and its sub-units. Acta Pathol Microbiol Scand. 1966;66(3):383–395. doi: 10.1111/apm.1966.66.3.383. [DOI] [PubMed] [Google Scholar]
- OSTERLAND C. K., HARBOE M., KUNKEL H. G. Anti-gamma-globulin factors in human sera revealed by enzymatic splitting of anti-Rh antibodies. Vox Sang. 1963 Mar-Apr;8:133–152. doi: 10.1111/j.1423-0410.1963.tb03290.x. [DOI] [PubMed] [Google Scholar]
- WALLER M. V., DECKER B., TOONE E. C., Jr, IRBY R. Evaluation of rheumatoid factor tests. Arthritis Rheum. 1961 Dec;4:579–591. doi: 10.1002/art.1780040604. [DOI] [PubMed] [Google Scholar]
- WILLIAMS R. C., Jr, KUNKEL H. G. Antibodies to rabbit gamma-globulin after immunizing with various preparations of autologous gamma-globulin. Proc Soc Exp Biol Med. 1963 Mar;112:554–561. doi: 10.3181/00379727-112-28104. [DOI] [PubMed] [Google Scholar]
- WILLIAMS R. C., Jr, KUNKEL H. G. Rheumatoid factor, complement, and conglutinin aberrations in patients with subacute bacterial endocarditis. J Clin Invest. 1962 Mar;41:666–675. doi: 10.1172/JCI104523. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waller M., Blaylock K. Further studies on the anti-globulin factors in human serum to the pepsin digested fragment of the Ri anti-Rh antibody. J Immunol. 1966 Sep;97(3):438–443. [PubMed] [Google Scholar]
- Waller M., Curry N., Mallory J. Immunochemical and serological studies of enzymatically fractionated human IgG globulins. I. Hydrolysis with pepsin, papain, ficin and bromelin. Immunochemistry. 1968 Nov;5(6):577–583. doi: 10.1016/0019-2791(68)90093-1. [DOI] [PubMed] [Google Scholar]
- Waller M., Curry N., Richard A. Serological specificity of IgG and IgM antiglobulin antibodies in anti-Gm(a) antisera. Clin Exp Immunol. 1968 Sep;3(7):631–640. [PMC free article] [PubMed] [Google Scholar]
- Waller M. Methods of measurement of rheumatoid factor. Ann N Y Acad Sci. 1969 Dec 10;168(1):5–16. doi: 10.1111/j.1749-6632.1969.tb43090.x. [DOI] [PubMed] [Google Scholar]
- Waller M., Richard A. J., Mallory J. Immunochemical and serological studies of enzymaatically fragmented human IgG globulins. II. Hydrolysis with subtilisin, elastase, trypsin, and chymotrypsin. Immunochemistry. 1969 Mar;6(2):207–214. doi: 10.1016/0019-2791(69)90157-8. [DOI] [PubMed] [Google Scholar]
- Waller M. Serum agglutinators of erythrocytes sensitized with enzyme digested anti-Rh antibodies. Vox Sang. 1967 Sep;13(3):233–245. doi: 10.1111/j.1423-0410.1967.tb03393.x. [DOI] [PubMed] [Google Scholar]
- Williams R. C., Jr, Lawrence T. G., Jr Variations among gamma-globulins at the antigenic site revealed by pepsin digestion. J Clin Invest. 1966 May;45(5):714–723. doi: 10.1172/JCI105386. [DOI] [PMC free article] [PubMed] [Google Scholar]