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. 1971 Mar;8(3):479–490.

The genetic basis of autoimmunity in NZB mice studied by progeny-testing

A Ghaffar, J H L Playfair
PMCID: PMC1712929  PMID: 4930642

Abstract

NZB mice were mated to NZW and to Balb/c, and the F1, F2 and backcross progeny tested for the incidence of red-cell autoantibodies, glomerulonephritis, and anti-nuclear antibodies. Evidence was found for some segregation of these autoimmune characteristics, and the results were interpreted as favouring an underlying genetic basis, though not a simple one.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIELSCHOWSKY M., BIELSCHOWSKY F. OBSERVATIONS ON NZB/B1 MICE; DIFFERENTIAL FERTILITY IN RECIPROCAL CROSSES AND THE TRANSMISSION OF THE AUTO-IMMUNE HAEMOLYTIC ANAEMIA TO NZB/B1 X NZC/B1 HYBRIDS. Aust J Exp Biol Med Sci. 1964 Aug;42:561–568. [PubMed] [Google Scholar]
  2. Barnes R. D., Tuffrey M. Serum antinuclear factor and the influence of environment in mice. Nature. 1967 Jun 10;214(5093):1136–1138. doi: 10.1038/2141136a0. [DOI] [PubMed] [Google Scholar]
  3. Braverman I. M. Study of autoimmune disease in New Zealand mice. I. Genetic features and natural history of NZB, NZY and NZW strains and NZB-NZW hybrids. J Invest Dermatol. 1968 Jun;50(6):483–499. doi: 10.1038/jid.1968.79. [DOI] [PubMed] [Google Scholar]
  4. Burnet M., Holmes M. C. Genetic investigations of autoimmune disease in mice. Nature. 1965 Jul 24;207(995):368–371. doi: 10.1038/207368a0. [DOI] [PubMed] [Google Scholar]
  5. East J., de Sousa M. A., Parrott D. M. Immunopathology of New Zealand black (NZB) mice. Transplantation. 1965 Nov;3(6):711–729. doi: 10.1097/00007890-196511000-00003. [DOI] [PubMed] [Google Scholar]
  6. Flad H. D., Playfair J. H., Ghaffar A., Miescher P. A. Strain differences in the liver autoantibody response of inbred mice. Proc Soc Exp Biol Med. 1969 May;131(1):121–124. doi: 10.3181/00379727-131-33818. [DOI] [PubMed] [Google Scholar]
  7. HOLBOROW E. J., WEIR D. M., JOHNSON G. D. A serum factor in lupus erythematosus with affinity for tissue nuclei. Br Med J. 1957 Sep 28;2(5047):732–734. doi: 10.1136/bmj.2.5047.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOLMES M. C., BURNET F. M. THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS. Ann Intern Med. 1963 Sep;59:265–276. doi: 10.7326/0003-4819-59-3-265. [DOI] [PubMed] [Google Scholar]
  9. Howie J. B., Helyer B. J. Autoimmune disease in mice. Ann N Y Acad Sci. 1965 Jun 30;124(1):167–177. doi: 10.1111/j.1749-6632.1965.tb18955.x. [DOI] [PubMed] [Google Scholar]
  10. LONG G., HOLMES M. C., BURNET F. M. AUTOANTIBODIES PRODUCED AGAINST MOUSE ERYTHROCYTES IN NZB MICE. Aust J Exp Biol Med Sci. 1963 Aug;41:315–322. doi: 10.1038/icb.1963.31. [DOI] [PubMed] [Google Scholar]
  11. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McDevitt H. O., Sela M. Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med. 1965 Sep 1;122(3):517–531. doi: 10.1084/jem.122.3.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mellors R. C., Aoki T., Huebner R. J. Further implication of murine leukemia-like virs in the disorders of NZB mice. J Exp Med. 1969 May 1;129(5):1045–1062. doi: 10.1084/jem.129.5.1045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy. J Exp Med. 1966 Dec 1;124(6):1031–1038. doi: 10.1084/jem.124.6.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. NORINS L. C., HOLMES M. C. ANTINUCLEAR FACTOR IN MICE. J Immunol. 1964 Jul;93:148–154. [PubMed] [Google Scholar]
  16. Playfair J. H., Krsiakova M. Syngeneic splenomegaly in NZB and BALB-c mice. Transplantation. 1969 May;7(5):443–444. doi: 10.1097/00007890-196905000-00029. [DOI] [PubMed] [Google Scholar]
  17. Playfair J. H. Strain differences in the immune response of mice. II. Responses by neonatal cells in irradiated adult hosts. Immunology. 1968 Dec;15(6):815–826. [PMC free article] [PubMed] [Google Scholar]
  18. Roitt I. M., Doniach D. Autoimmunity and disease. Sci Basis Med Annu Rev. 1965:110–123. [PubMed] [Google Scholar]
  19. Seligmann M., Danon F., Mihaesco C., Fudenberg H. H. Immunoglobulin abnormalities in families of patients with Waldenström's macroglobulinemia. Am J Med. 1967 Jul;43(1):66–83. doi: 10.1016/0002-9343(67)90149-0. [DOI] [PubMed] [Google Scholar]
  20. Staples P. J., Talal N. Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice. J Exp Med. 1969 Jan 1;129(1):123–139. doi: 10.1084/jem.129.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. de Vries M. J., Hijmans W. Pathological changes of thymic epithelial cells and autoimmune disease in NZB, NZW and (NZB x NZW)F1 mice. Immunology. 1967 Feb;12(2):179–196. [PMC free article] [PubMed] [Google Scholar]

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