Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1971 Nov;9(5):577–583.

A comparison of the immunoglobulins, IgA, IgG and IgE in nasal secretions from normal and asthmatic children

J D Hobday, M Cake, K J Turner
PMCID: PMC1713052  PMID: 5004280

Abstract

The secreted proteins obtained from nasal washings from eighty-five normal children and fifty asthmatic children, between 6 and 14 years, were investigated by immunological assay for their content of albumin, secretory IgA and IgG. A smaller number of specimens from asthmatic and normal children were examined for their IgE content. There was no statistically significant difference in the levels of albumin, secretory IgA and IgG in the asthmatic and the normal children. The IgE content of nasal wash protein in normal children averaged approximately 70 ng/mg of protein, whereas the IgE content in the asthmatic children averaged greater than 400 ng/mg of wash protein.

Full text

PDF
577

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alford R. H. Effects of chronic bronchopulmonary disease and aging on human nasal secretion IgA concentrations. J Immunol. 1968 Nov;101(5):984–988. [PubMed] [Google Scholar]
  2. Arturson G., Högman C. F., Johansson S. G., Killander J. Changes in immunoglobulin levels in severely burned patients. Lancet. 1969 Mar 15;1(7594):546–548. doi: 10.1016/s0140-6736(69)91957-6. [DOI] [PubMed] [Google Scholar]
  3. Berg T., Johansson S. G. IgE concentrations in children with atopic diseases. A clinical study. Int Arch Allergy Appl Immunol. 1969;36(3):219–232. doi: 10.1159/000230745. [DOI] [PubMed] [Google Scholar]
  4. Cohen A. B., Goldberg S., London R. L. Immunoglobulins in nasal secretions of infants. Clin Exp Immunol. 1970 May;6(5):753–760. [PMC free article] [PubMed] [Google Scholar]
  5. Donovan R., Johansson S. G., Bennich H., Soothill J. F. Immunoglobulins in nasal polyp fluid. Int Arch Allergy Appl Immunol. 1970;37(2):154–166. doi: 10.1159/000230229. [DOI] [PubMed] [Google Scholar]
  6. Ishizaka K., Ishizaka T. Identification of gamma-E-antibodies as a carrier of reaginic activity. J Immunol. 1967 Dec;99(6):1187–1198. [PubMed] [Google Scholar]
  7. Ishizaka K., Newcomb R. W. Presence of gammaE in nasal washings and sputum from asthmatic patients. J Allergy. 1970 Oct;46(4):197–204. doi: 10.1016/0021-8707(70)90023-7. [DOI] [PubMed] [Google Scholar]
  8. Johansson S. G. Raised levels of a new immunoglobulin class (IgND) in asthma. Lancet. 1967 Nov 4;2(7523):951–953. doi: 10.1016/s0140-6736(67)90792-1. [DOI] [PubMed] [Google Scholar]
  9. Johansson S. G. Serum IgND levels in healthy children and adults. Int Arch Allergy Appl Immunol. 1968;34(1):1–8. doi: 10.1159/000230089. [DOI] [PubMed] [Google Scholar]
  10. Lichtenstein L. M., Holtzman N. A., Burnett L. S. A quantitative in vitro study of the chromatographic distribution and immunoglobulin characteristics of human blocking antibody. J Immunol. 1968 Aug;101(2):317–324. [PubMed] [Google Scholar]
  11. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  12. Newcomb R. W., Normansell D., Stanworth D. R. A structural study of human exocrine IgA globulin. J Immunol. 1968 Nov;101(5):905–914. [PubMed] [Google Scholar]
  13. Rossen R. D., Butler W. T., Cate T. R., Szwed C. F., Couch R. B. Protein composition of nasal secretion during respiratory virus infection. Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1169–1176. doi: 10.3181/00379727-119-30406. [DOI] [PubMed] [Google Scholar]
  14. Rowe D. S. Radioactive single radial diffusion: a method for increasing the sensitivity of immunochemical quantification of proteins in agar gel. Bull World Health Organ. 1969 Apr;40(4):613–616. [PMC free article] [PubMed] [Google Scholar]
  15. Smith C. B., Bellanti J. A., Chanock R. M. Immunoglobulins in serum and nasal secretions following infection with type 1 parainfluenza virus and injection of inactivated vaccines. J Immunol. 1967 Jul;99(1):133–141. [PubMed] [Google Scholar]
  16. TOMASI T. B., Jr, TAN E. M., SOLOMON A., PRENDERGAST R. A. CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS. J Exp Med. 1965 Jan 1;121:101–124. doi: 10.1084/jem.121.1.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tada T., Ishizaka K. Distribution of gamma E-forming cells in lymphoid tissues of the human and monkey. J Immunol. 1970 Feb;104(2):377–387. [PubMed] [Google Scholar]
  18. Townley R. G., Trapani I. L., Szentivanyi A. Sensitization to anaphylaxis and to some of its pharmacological mediators by blockade of the beta adrenergic receptors. J Allergy. 1967 Mar;39(3):177–197. doi: 10.1016/0021-8707(67)90036-6. [DOI] [PubMed] [Google Scholar]
  19. Tse K. S., Wicher K., Arbesman C. E. IgE antibodies in nasal secretions of ragweed-allergic subjects. J Allergy. 1970 Dec;46(6):352–357. doi: 10.1016/0021-8707(70)90086-9. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES