Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1971 Sep;9(3):371–380.

Kinetics of the distribution of thymus and marrow cells in the peripheral lymphoid organs of the mouse: ecotaxis

Maria de Sousa
PMCID: PMC1713071  PMID: 5571056

Abstract

The differences between the fate of mouse thymus and marrow cells labelled in vitro with [3H]adenosine following intravenous injection into syngeneic recipients are defined. Thymus cells home predominantly to the thymus–dependent territory in the recipient's peripheral lymphoid organs, whereas the majority of bone marrow cells is found in thymus–independent sites. In addition, it is shown that a marrow inoculum contains a variety of sub-populations able to discriminate microenvironmental differences within the thymus–independent territory itself. In general, cell populations behave as if they have the ability to distinguish and home towards what is probably their usual environment. The word `ecotaxis' is offered to define this phenomenon, and the mechanisms that may be involved in determining it are discussed.

Full text

PDF
371

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Austin C. M. Patterns of migration of lymphoid cells. Aust J Exp Biol Med Sci. 1968 Oct;46(5):581–593. doi: 10.1038/icb.1968.165. [DOI] [PubMed] [Google Scholar]
  2. BOYDEN S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med. 1962 Mar 1;115:453–466. doi: 10.1084/jem.115.3.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Berney S. N., Gesner B. M. The circulatory behaviour of normal and enzyme altered thymocytes in rats. Immunology. 1970 May;18(5):681–691. [PMC free article] [PubMed] [Google Scholar]
  4. Cleveland W. W., Fogel B. J., Brown W. T., Kay H. E. Foetal thymic transplant in a case of Digeorge's syndrome. Lancet. 1968 Dec 7;2(7580):1211–1214. doi: 10.1016/s0140-6736(68)91694-2. [DOI] [PubMed] [Google Scholar]
  5. De Sousa M. A., Parrott D. M., Pantelouris E. M. The lymphoid tissues in mice with congenital aplasia of the thymus. Clin Exp Immunol. 1969 Jun;4(6):637–644. [PMC free article] [PubMed] [Google Scholar]
  6. Dresser D. W., Taub R. N., Krantz A. R. The effect of localized injection of adjuvant material on the draining lymph node. II. Circulating lymphocytes. Immunology. 1970 May;18(5):663–670. [PMC free article] [PubMed] [Google Scholar]
  7. GOWANS J. L., KNIGHT E. J. THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT. Proc R Soc Lond B Biol Sci. 1964 Jan 14;159:257–282. doi: 10.1098/rspb.1964.0001. [DOI] [PubMed] [Google Scholar]
  8. Goldschneider I., McGregor D. D. Migration of lymphocytes and thymocytes in the rat. II. Circulation of lymphocytes and thymocytes from blood to lymph. Lab Invest. 1968 Apr;18(4):397–406. [PubMed] [Google Scholar]
  9. Mosier D. E. A requirement for two cell types for antibody formation in vitro. Science. 1967 Dec 22;158(3808):1573–1575. doi: 10.1126/science.158.3808.1573. [DOI] [PubMed] [Google Scholar]
  10. Mosier D. E., Fitch F. W., Rowley D. A., Davies A. J. Cellular deficit in thymectomized mice. Nature. 1970 Jan 17;225(5229):276–277. doi: 10.1038/225276a0. [DOI] [PubMed] [Google Scholar]
  11. Parrott D. V., De Sousa M. A., East J. Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J Exp Med. 1966 Jan 1;123(1):191–204. doi: 10.1084/jem.123.1.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sainte-Marie G., Sin Y. M. Reticular fiber pattern in the rat spleen. Rev Can Biol. 1968 Sep;27(3):273–275. [PubMed] [Google Scholar]
  13. Taub R. N., Krantz A. R., Dresser D. W. The effect of localized injection of adjuvant material on the draining lymph node. I. Histology. Immunology. 1970 Feb;18(2):171–186. [PMC free article] [PubMed] [Google Scholar]
  14. WAKSMAN B. H., ARNASON B. G., JANKOVIC B. D. Role of the thymus in immune reactions in rats. III. Changes in the lymphoid organs of thymectomized rats. J Exp Med. 1962 Aug 1;116:187–206. doi: 10.1084/jem.116.2.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Woodruff J. J., Gesner B. M. The effect of neuraminidase on the fate of transfused lymphocytes. J Exp Med. 1969 Mar 1;129(3):551–567. doi: 10.1084/jem.129.3.551. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES