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. 1971 Sep;9(3):305-310, 311.

Progressive loss in vitro of cellular immunity with ageing in strains of mice susceptible to autoimmune disease*

G E Rodey, R A Good, E J Yunis
PMCID: PMC1713078  PMID: 5571055

Abstract

The influence of ageing on the in vitro responses of mouse spleen cells to phytohaemagglutinin and to allogeneic cells was studied in NZB, (NZB×A)F1, A and CBA mice. These responses decline with ageing in those strains which are genetically susceptible to autoimmune disease (NZB, (NZB×A)F1 and A) but not in a non-susceptible strain (CBA). These studies support the view that cellular immunity declines with advancing age in autoimmune-susceptible mice, and suggests that the decline is due to a progressive loss of the thymus-dependent cell pool.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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