Abstract
Naturally occurring titres of heterophil haemagglutinins against rat erythrocytes are related to ABO blood groups, being higher in people of blood groups O and A and lower in people of blood groups B and AB. Comparable titres of haemagglutinin activity can be demonstrated against human AB erythrocytes as well as rat erythrocytes. Activity against rat erythrocytes can be absorbed with human AB erythrocytes and vice versa. Furthermore, after absorption of heterophil antibody with human A or B erythrocytes, heat elution allows partial recovery of the antibody which reacts with rat erythrocytes. A rise in titre of heterophil antibody comparable to that occurring after renal transplantation was demonstrated after surgical operations but only where blood transfusions were given. It is postulated that these rises in antibody titre result from exposure to non-HL-A isoantigens which crossreact with human A and B substance and rat erythrocyte antigens. These antibodies can be distinguished from Forsmann and infectious mononucleosis antibodies, are absent in placental cord blood, occur naturally as IgM and respond to a secondary challenge as IgG, except in immunosuppressed renal transplant patients, where both IgG and IgM responses occur.
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Selected References
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