Abstract
A patient is presented who has recurrent infections associated with a cellular defect of PMN chemotaxis and phagocytosis, as well as a sex-linked form of congenital agammaglobulinaemia. The impairments of PMN function were demonstrated in vitro by an inability of the patient's PMNs to respond to chemotactic factors, by an inability of the PMNs to phagocytize S. aureus, and by abnormal NBT tests. These abnormalities were not corrected by the addition of normal serum or plasma to the patient's PMNs. No evidence was obtained for a plasma inhibitor of PMN function.
Full text
PDF







Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alexander J. W., Windhorst D. B., Good R. A. Improved tests for the evaluation of neutrophil function in human disease. J Lab Clin Med. 1968 Jul;72(1):136–148. [PubMed] [Google Scholar]
- Baehner R. L., Nathan D. G. Quantitative nitroblue tetrazolium test in chronic granulomatous disease. N Engl J Med. 1968 May 2;278(18):971–976. doi: 10.1056/NEJM196805022781801. [DOI] [PubMed] [Google Scholar]
- Good R. A., Quie P. G., Windhorst D. B., Page A. R., Rodey G. E., White J., Wolfson J. J., Holmes B. H. Fatal (chronic) granulomatous disease of childhood: a hereditary defect of leukocyte function. Semin Hematol. 1968 Jul;5(3):215–254. [PubMed] [Google Scholar]
- Mickenberg I. D., Root R. K., Wolff S. M. Leukocytic function in hypogammaglobulinemia. J Clin Invest. 1970 Aug;49(8):1528–1538. doi: 10.1172/JCI106370. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller M. E., Nilsson U. R. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5). N Engl J Med. 1970 Feb 12;282(7):354–358. doi: 10.1056/NEJM197002122820702. [DOI] [PubMed] [Google Scholar]
- REBUCK J. W., CROWLEY J. H. A method of studying leukocytic functions in vivo. Ann N Y Acad Sci. 1955 Mar 24;59(5):757–805. doi: 10.1111/j.1749-6632.1955.tb45983.x. [DOI] [PubMed] [Google Scholar]
- Shin H. S., Mayer M. M. The third component of the guinea pig complement system. II. Kinetic study of the reaction of EAC'4,2a with guinea pig C'3. Enzymatic nature of C'3 comsumption, multiphasic character of fixation, and hemolytic titration of C'3. Biochemistry. 1968 Aug;7(8):2997–3002. doi: 10.1021/bi00848a041. [DOI] [PubMed] [Google Scholar]
- Snyderman R., Gewurz H., Mergenhagen S. E. Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. J Exp Med. 1968 Aug 1;128(2):259–275. doi: 10.1084/jem.128.2.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Snyderman R., Shin H. S., Phillips J. K., Gewurz H., Mergenhagen S. E. A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin. J Immunol. 1969 Sep;103(3):413–422. [PubMed] [Google Scholar]
- Ward P. A., Schlegel R. J. Impaired leucotactic responsiveness in a child with recurrent infections. Lancet. 1969 Aug 16;2(7616):344–347. doi: 10.1016/s0140-6736(69)92699-3. [DOI] [PubMed] [Google Scholar]
- Windhorst D. B., Holmes B., Good R. A. A newly defined X-linked trait in man with demonstration of the Lyon effect in carrier females. Lancet. 1967 Apr 8;1(7493):737–739. doi: 10.1016/s0140-6736(67)91360-8. [DOI] [PubMed] [Google Scholar]