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. 1972 Mar;10(3):399–407.

Antigenic relationship between human IgE and canine IgE

R E W Halliwell, R M Schwartzman, J H Rockey
PMCID: PMC1713153  PMID: 4624496

Abstract

Absorption of canine reaginic serum with anti-human IgE resulted in a substantial reduction in PK titre to ragweed. Anti-human IgE was also effective in eliciting reversed cutaneous anaphylaxis in the dog. This is conclusive evidence of antigenic similarity of canine and human IgE. The immunoelectrophoretic identification of canine IgE is described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Halliwell R. E. Atopic disease in the dog. Vet Rec. 1971 Aug 21;89(8):209–214. doi: 10.1136/vr.89.8.209. [DOI] [PubMed] [Google Scholar]
  2. Hubscher T., Watson J. I., Goodfriend L. Target cells of human ragweed-binding antibodies in monkey skin. I. Immunofluorescent localization of cellular binding. J Immunol. 1970 May;104(5):1187–1195. [PubMed] [Google Scholar]
  3. Ishizaka K., Ishizaka T., Hornbrook M. M. Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J Immunol. 1966 Jul;97(1):75–85. [PubMed] [Google Scholar]
  4. Ishizaka K., Ishizaka T., Menzel A. E. Physicochemical properties of reaginic antibody. VI. Effect of heat on gamma-E-, gamma-G- and gamma-A-antibodies in the sera of ragweed sensitive patients. J Immunol. 1967 Sep;99(3):610–618. [PubMed] [Google Scholar]
  5. Ishizaka K., Ishizaka T. Reversed type allergic skin reactions by anti-gamma-E-globulin antibodies in humans and monkeys. J Immunol. 1968 Mar;100(3):554–562. [PubMed] [Google Scholar]
  6. Johansson S. G., Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology. 1967 Oct;13(4):381–394. [PMC free article] [PubMed] [Google Scholar]
  7. Johnson J. S., Vaughan J. H. Canine immunoglobulins. I. Evidence for six immunoglobulin classes. J Immunol. 1967 May;98(5):923–934. [PubMed] [Google Scholar]
  8. Montgomery P. C., Dorrington K. J., Rockey J. H. Equine antihapten antibody. The molecular weights of the subunits of equine immunoglobulins. Biochemistry. 1969 Mar;8(3):1247–1258. doi: 10.1021/bi00831a060. [DOI] [PubMed] [Google Scholar]
  9. Parish W. E. Detection of reagins, IgG, IgA and IgM antibodies in human sera. Int Arch Allergy Appl Immunol. 1969;36(3):245–265. doi: 10.1159/000230747. [DOI] [PubMed] [Google Scholar]
  10. Rockey J. H., Montgomery P. C., Dorrington K. J. Equine antihapten antibody. Studies on the primary structure and conformation of equine immunoglobulins. Biochemistry. 1970 Oct 27;9(22):4310–4321. doi: 10.1021/bi00824a011. [DOI] [PubMed] [Google Scholar]
  11. Rockey J. H., Schwartzman R. M. Skin sensitizing antibodies: a comparative study of canine and human PK and PCA antibodies and a canine myeloma protein. J Immunol. 1967 Jun;98(6):1143–1151. [PubMed] [Google Scholar]
  12. Schwartzman R. M., Rockey J. H., Halliwell R. E. Canine reaginic antibody. Characterization of the spontaneous anti-ragweed and induced anti-dinitrophenyl reaginic antibodies of the atopic dog. Clin Exp Immunol. 1971 Nov;9(5):549–569. [PMC free article] [PubMed] [Google Scholar]
  13. Stanworth D. R., Humphrey J. H., Bennich H., Johansson S. G. Specific inhibition of the Prausnitz-Küstner reaction by an atypical human myeloma protein. Lancet. 1967 Aug 12;2(7511):330–332. doi: 10.1016/s0140-6736(67)90171-7. [DOI] [PubMed] [Google Scholar]
  14. Stechschulte D. J., Orange R. P., Austen K. F. Immunochemical and biologic properties of rat IgE. I. Immunochemical identification of rat IgE. J Immunol. 1970 Nov;105(5):1082–1086. [PubMed] [Google Scholar]
  15. Vaerman J. P., Heremans J. F. The immunoglobulins of the dog. II. The immunoglobulins of canine secretions. Immunochemistry. 1969 Nov;6(6):779–786. doi: 10.1016/0019-2791(69)90284-5. [DOI] [PubMed] [Google Scholar]
  16. Weir R. C., Porter R. R., Givol D. Comparison of the C-terminal amino-acid sequence of two horse immunoglobulins IgG and IgG(T). Nature. 1966 Oct 8;212(5058):205–206. doi: 10.1038/212205a0. [DOI] [PubMed] [Google Scholar]
  17. Zvaifler N. J., Robinson J. O. Rabbit homocytotropic antibody. A unique rabbit immunoglobulin analogous to human IgE. J Exp Med. 1969 Oct 1;130(4):907–929. doi: 10.1084/jem.130.4.907. [DOI] [PMC free article] [PubMed] [Google Scholar]

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