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. 1981 Sep;39(3):894–902. doi: 10.1128/jvi.39.3.894-902.1981

Nonstructural proteins of herpes simplex virus. II. Major virus-specific DNa-binding protein.

K L Powell, E Littler, D J Purifoy
PMCID: PMC171323  PMID: 6270358

Abstract

The major herpes simplex virus type 2 DNA-binding infected cell-specific polypeptides 11 and 12 have been purified to homogeneity from extracts of virus-infected cells. Monospecific antiserum to the purified protein has been made and used to examine virus temperature-sensitive mutants for defects in the synthesis of the protein and to probe virus DNA synthesis in isolated chromatin. The purified protein acted directly on a polydeoxyadenylic acid-polydeoxythymidylic acid helix, reducing its melting temperature. The results indicated that the protein functions in virus DNA synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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