Abstract
Three hundred and seventy sedentary men aged 20-65 years enrolled in a physical training programme after a medical and fitness examination that included measurements of "classical" risk factors for coronary heart disease. Five years later re-examination showed (a) that on average the subjects had not changed significantly in weight, blood pressure, serum lipid concentrations, smoking habits, and physical working capacity; (b) that men who had remained active and therefore had a higher degree of fitness did not differ in risk factors from men who had returned to sedentary habits; and (c) that men who had improved substantially in fitness did not differ in risk factors from men whose fitness had not changed or had declined. Five years after the initial programme one-third of the men were continuing with regular vigorous exercise. These results do not support the view that classical risk factors for coronary heart disease improve with increased physical activity and fitness.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allain C. C., Poon L. S., Chan C. S., Richmond W., Fu P. C. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470–475. [PubMed] [Google Scholar]
- Bassey E. J. Age, inactivity and some physiological responses to exercise. Gerontology. 1978;24(1):66–77. doi: 10.1159/000212238. [DOI] [PubMed] [Google Scholar]
- Bucolo G., David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973 May;19(5):476–482. [PubMed] [Google Scholar]
- Cooper K. H., Pollock M. L., Martin R. P., White S. R., Linnerud A. C., Jackson A. Physical fitness levels vs selected coronary risk factors. A cross-sectional study. JAMA. 1976 Jul 12;236(2):166–169. [PubMed] [Google Scholar]
- Fox S. M., 3rd, Haskell W. L. Physical activity and the prevention of coronary heart disease. Bull N Y Acad Med. 1968 Aug;44(8):950–967. [PMC free article] [PubMed] [Google Scholar]
- Fox S. M., 3rd, Naughton J. P., Haskell W. L. Physical activity and the prevention of coronary heart disease. Ann Clin Res. 1971 Dec;3(6):404–432. [PubMed] [Google Scholar]
- Friedlaender J. S., Costa P. T., Jr, Bosse R., Ellis E., Rhoads J. G., Stoudt H. W. Longitudinal physique changes among healthy white veterans at Boston. Hum Biol. 1977 Dec;49(4):541–558. [PubMed] [Google Scholar]
- Goldbourt U., Medalie J. H. Weight-height indices. Choice of the most suitable index and its association with selected variables among 10,000 adult males of heterogeneous origin. Br J Prev Soc Med. 1974 May;28(2):116–126. doi: 10.1136/jech.28.2.116. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hickey N., Mulcahy R., Bourke G. J., Graham I., Wilson-Davis K. Study of coronary risk factors related to physical activity in 15 171 men. Br Med J. 1975 Aug 30;3(5982):507–509. doi: 10.1136/bmj.3.5982.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ilmarinen J., Fardy P. S. Physical activity intervention for males with high risk of coronary heart disease: a three-year follow-up. Prev Med. 1977 Sep;6(3):416–425. doi: 10.1016/0091-7435(77)90024-x. [DOI] [PubMed] [Google Scholar]
- LEVINE J. B., ZAK B. AUTOMATED DETERMINATION OF SERUM TOTAL CHOLESTEROL. Clin Chim Acta. 1964 Oct;10:381–384. doi: 10.1016/0009-8981(64)90073-7. [DOI] [PubMed] [Google Scholar]
- Morris J. N., Chave S. P., Adam C., Sirey C., Epstein L., Sheehan D. J. Vigorous exercise in leisure-time and the incidence of coronary heart-disease. Lancet. 1973 Feb 17;1(7799):333–339. doi: 10.1016/s0140-6736(73)90128-1. [DOI] [PubMed] [Google Scholar]
- Nestel P. J., Quinlivan N., Roxburgh H. Possible usefulness of screening for hyperlipidaemia. Med J Aust. 1977 Aug 13;2(7):203–205. doi: 10.5694/j.1326-5377.1977.tb99137.x. [DOI] [PubMed] [Google Scholar]
- Paffenbarger R. S., Hale W. E. Work activity and coronary heart mortality. N Engl J Med. 1975 Mar 13;292(11):545–550. doi: 10.1056/NEJM197503132921101. [DOI] [PubMed] [Google Scholar]
- Paffenbarger R. S., Jr, Wing A. L., Hyde R. T. Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol. 1978 Sep;108(3):161–175. doi: 10.1093/oxfordjournals.aje.a112608. [DOI] [PubMed] [Google Scholar]
- Rosing D. R., Brakman P., Redwood D. R., Goldstein R. E., Beiser G. D., Astrup T., Epstein S. E. Blood fibrinolytic activity in man. Diurnal variation and the response to varying intensities of exercise. Circ Res. 1970 Aug;27(2):171–184. doi: 10.1161/01.res.27.2.171. [DOI] [PubMed] [Google Scholar]
- Sedgwick A. W., Craig R. J., Crouch R., Dowling B. The effects of physical training on the day and night long-term heart-rates of middle-aged men. Eur J Appl Physiol Occup Physiol. 1974;33(4):307–314. doi: 10.1007/BF00430238. [DOI] [PubMed] [Google Scholar]
- Simons L. A., Jones A. S. Coronary risk factor screening and long-term follow up: year 1 of the Sydney Coronary Heart Disease Prevention Programme. Med J Aust. 1978 Nov 4;2(10):455–458. doi: 10.5694/j.1326-5377.1978.tb131640.x. [DOI] [PubMed] [Google Scholar]
- Taylor H. L., Buskirk E. R., Remington R. D. Exercise in controlled trials of the prevention of coronary heart disease. Fed Proc. 1973 May;32(5):1623–1627. [PubMed] [Google Scholar]
- Thomas G. S. Physical activity and health: epidemiologic and clinical evidence and policy implications. Prev Med. 1979 Jan;8(1):89–103. doi: 10.1016/0091-7435(79)90032-x. [DOI] [PubMed] [Google Scholar]
- Walker W. J. Changing United States life-style and declining vascular mortality: cause or coincidence? N Engl J Med. 1977 Jul 21;297(3):163–165. doi: 10.1056/NEJM197707212970311. [DOI] [PubMed] [Google Scholar]
- Welborn T. A., Cumpston G. N., Cullen K. J., Curnow D. H., McCall M. G., Stenhouse N. S. The prevalence of coronary heart disease and associated factors in an Australian rural community. Am J Epidemiol. 1969 May;89(5):521–536. doi: 10.1093/oxfordjournals.aje.a120965. [DOI] [PubMed] [Google Scholar]
- Welborn T. A., Murphy B. P., Stewart A. J., Fullerton R., Finch P. S. Prevalence of cardiovascular risk factors including fasting serum triglyceride levels in the Cunderdin health survey of 1971. Med J Aust. 1976 Aug 7;2(6):199–204. doi: 10.5694/j.1326-5377.1976.tb130107.x. [DOI] [PubMed] [Google Scholar]
- Wood P. D., Haskell W. L. The effect of exercise on plasma high density lipoproteins. Lipids. 1979 Apr;14(4):417–427. doi: 10.1007/BF02533428. [DOI] [PubMed] [Google Scholar]
- du V Florey C., Melia R. J., Darby S. C. Changing mortality from ischaemic heart disease in Great Britain 1968-76. Br Med J. 1978 Mar 11;1(6113):635–637. doi: 10.1136/bmj.1.6113.635. [DOI] [PMC free article] [PubMed] [Google Scholar]