Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1981 Aug;39(2):651–655. doi: 10.1128/jvi.39.2.651-655.1981

Epstein-Barr Virus Polypeptides: Identification of Early Proteins and Their Synthesis and Glycosylation

Robert J Feighny 1, Berch E Henry II 1, Joseph S Pagano 2
PMCID: PMC171376  PMID: 6268851

Abstract

We have identified at least six early polypeptides induced by Epstein-Barr virus in cells or under conditions which are nonpermissive for Epstein-Barr virus DNA replication ranging in molecular weight from 140,000 to 26,000.

Full text

PDF
651

Images in this article

653Image
on p.653
654Image
on p.654

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bayliss G. J., Nonoyama M. Mechanisms of infection with Epstein-Barr virus. III. The synthesis of proteins in superinfected Raji cells. Virology. 1978 Jun 1;87(1):204–207. doi: 10.1016/0042-6822(78)90173-3. [DOI] [PubMed] [Google Scholar]
  2. Bodemer W. W., Summers W. C., Niederman J. C. Detection of virus-specific antigens in EB-(P3HR1) virus-superinfected Raji cells by immunoprecipitation. Virology. 1980 Jun;103(2):340–349. doi: 10.1016/0042-6822(80)90192-0. [DOI] [PubMed] [Google Scholar]
  3. Colby B. M., Shaw J. E., Elion G. B., Pagano J. S. Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication. J Virol. 1980 May;34(2):560–568. doi: 10.1128/jvi.34.2.560-568.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Feighny R. J., Farrell M. P., Pagano J. S. Polypeptide synthesis and phosphorylation in Epstein-Barr virus-infected cells. J Virol. 1980 May;34(2):455–463. doi: 10.1128/jvi.34.2.455-463.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Feighny R. J., Henry B. E., 2nd, Datta A. K., Pagano J. S. Induction of DNA polymerase activity after superinfection of Raji cells with Epstein-Barr virus. Virology. 1980 Dec;107(2):415–423. doi: 10.1016/0042-6822(80)90308-6. [DOI] [PubMed] [Google Scholar]
  6. Feighny R. J., Henry B. E., 2nd, Pagano J. S. Epstein-Barr virus polypeptides: effect of inhibition of viral DNA replication on their synthesis. J Virol. 1981 Jan;37(1):61–71. doi: 10.1128/jvi.37.1.61-71.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Honess R. W., Roizman B. Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J Virol. 1974 Jul;14(1):8–19. doi: 10.1128/jvi.14.1.8-19.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kallin B., Luka J., Klein G. Immunochemical characterization of Epstein-Barr virus-associated early and late antigens in n-butyrate-treated P3HR-1 cells. J Virol. 1979 Dec;32(3):710–716. doi: 10.1128/jvi.32.3.710-716.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mueller-Lantzsch N., Yamamoto N., zur Hausen H. Analysis of early and late Epstein-Barr virus associated polypeptides by immunoprecipitation. Virology. 1979 Sep;97(2):378–387. doi: 10.1016/0042-6822(79)90348-9. [DOI] [PubMed] [Google Scholar]
  10. Qualtiere L. F., Pearson G. R. Epstein-Barr virus-induced membrane antigens: immunochemical characterization of Triton X-100 solubilized viral membrane antigens from EBV-superinfected Raji cells. Int J Cancer. 1979 Jun 15;23(6):808–817. doi: 10.1002/ijc.2910230612. [DOI] [PubMed] [Google Scholar]
  11. Shaw J. E., Seebeck T., Li J. L., Pagano J. S. Epstein-Barr virus DNA synthesized in superinfected Raji cells. Virology. 1977 Apr;77(2):762–771. doi: 10.1016/0042-6822(77)90497-4. [DOI] [PubMed] [Google Scholar]
  12. Stinski M. F. Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides. J Virol. 1978 Jun;26(3):686–701. doi: 10.1128/jvi.26.3.686-701.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Summers W. C., Klein G. Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid. J Virol. 1976 Apr;18(1):151–155. doi: 10.1128/jvi.18.1.151-155.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Yajima Y., Nonoyama M. Mechanisms of infection with Epstein-Barr virus. I. Viral DNA replication and formation of noninfectious virus particles in superinfected Raji cells. J Virol. 1976 Jul;19(1):187–194. doi: 10.1128/jvi.19.1.187-194.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. zur Hausen H., O'Neill F. J., Freese U. K., Hecker E. Persisting oncogenic herpesvirus induced by the tumour promotor TPA. Nature. 1978 Mar 23;272(5651):373–375. doi: 10.1038/272373a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES