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. 1981 Aug;39(2):656–660. doi: 10.1128/jvi.39.2.656-660.1981

Structure of replicating herpes simplex virus DNA.

C V Jongeneel, S L Bachenheimer
PMCID: PMC171377  PMID: 6268852

Abstract

We have investigated the molecular anatomy of the herpes simplex virus replicative intermediates by cleavage with the restriction endonuclease BglII. We find that in populations of multiply infected cells, pulse-labeled replicating herpes simplex virus DNA contains at least two and probably all four sequence isomers. Also, it contains no detectable termini. In pulse-chase experiments, we show that endless replicative intermediates are the precursors to virion DNA and that maturation is a relatively slow process. The results are discussed in terms of their significance to possible models of herpes simplex virus DNA replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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