Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1980 Sep 20;281(6243):770–772. doi: 10.1136/bmj.281.6243.770

Changes in plasma high-density lipoprotein cholesterol concentration after weight reduction in grossly obese subjects.

D A Streja, E Boyko, S W Rabkin
PMCID: PMC1714030  PMID: 7427443

Abstract

Changes in serum lipoproteins associated with weight loss were assessed in 13 grossly obese (relative weight 183%) patients who had participated in an outpatient semi-starvation diet consisting of liquid protein and carbohydrate. At the follow-up examination an average of six and a half months after the start of refeeding the mean weight loss was 16.1 +/- 4.5 kg or 15% of initial body weight. Significant increases in high-density lipoprotein (HDL) cholesterol of 0.16 +/- 0.05 mmol/l (6 +/- 2 mg/100 ml) and decreases in triglycerides (0.8 +/- 0.23 mmol/l; 73 +/- 20 mg/100 ml) and fasting blood sugar (0.6 +/- 0.22 mmol/l; 11 +/- 4 mg/100 ml) were observed. Changes in HDL cholesterol correlated significantly with changes in weight (r = 0.667) and percentage change in weight. The intercept of the regression equation relating HDL cholesterol to percentage change in weight was -7.3, indicating that a change in HDL cholesterol greater than zero required a weight loss of at least 7.3% of body weight. Thus, weight loss can significantly increase HDL cholesterol concentrations but a considerable amount of weight must be lost to produce a significant increase in HDL cholesterol concentration.

Full text

PDF
770

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avogaro P., Cazzolato G., Bittolo Bon G., Quinci G. B., Chinello M. HDL-cholesterol, apolipoproteins A1 and B. Age and index body weight. Atherosclerosis. 1978 Sep;31(1):85–91. doi: 10.1016/0021-9150(78)90040-0. [DOI] [PubMed] [Google Scholar]
  2. Bistrian B. R., Blackburn G. L., Stanbury J. B. Metabolic aspects of a protein-sparing modified fast in the dietary management of Prader-Willi obesity. N Engl J Med. 1977 Apr 7;296(14):774–779. doi: 10.1056/NEJM197704072961402. [DOI] [PubMed] [Google Scholar]
  3. Bronzert T. J., Brewer H. B., Jr New micromethod for measuring cholesterol in plasma lipoprotein fractions. Clin Chem. 1977 Nov;23(11):2089–2098. [PubMed] [Google Scholar]
  4. Carlson L. A., Ericsson M. Quantitative and qualitative serum lipoprotein analysis. Part 1. Studies in healthy men and women. Atherosclerosis. 1975 May-Jun;21(3):417–433. doi: 10.1016/0021-9150(75)90054-4. [DOI] [PubMed] [Google Scholar]
  5. Garrison R. J., Kannel W. B., Feinleib M., Castelli W. P., McNamara P. M., Padgett S. J. Cigarette smoking and HDL cholesterol: the Framingham offspring study. Atherosclerosis. 1978 May;30(1):17–25. doi: 10.1016/0021-9150(78)90149-1. [DOI] [PubMed] [Google Scholar]
  6. Goldbourt U., Medalie J. H. High density lipoprotein cholesterol and incidence of coronary heart disease--the Israeli Ischemic Heart Disease Study. Am J Epidemiol. 1979 Mar;109(3):296–308. doi: 10.1093/oxfordjournals.aje.a112683. [DOI] [PubMed] [Google Scholar]
  7. Gordon T., Castelli W. P., Hjortland M. C., Kannel W. B., Dawber T. R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977 May;62(5):707–714. doi: 10.1016/0002-9343(77)90874-9. [DOI] [PubMed] [Google Scholar]
  8. Hulley S. B., Cohen R., Widdowson G. Plasma high-density lipoprotein cholesterol level. Influence of risk factor intervention. JAMA. 1977 Nov 21;238(21):2269–2271. [PubMed] [Google Scholar]
  9. Hulley S., Ashman P., Kuller L., Lasser N., Sherwin R. HDL-cholesterol levels in the Multiple Risk Factor Intervention Trial (MRFIT) by the MRFIT Research Group 1,2. Lipids. 1979 Jan;14(1):119–123. doi: 10.1007/BF02533580. [DOI] [PubMed] [Google Scholar]
  10. Isner J. M., Sours H. E., Paris A. L., Ferrans V. J., Roberts W. C. Sudden, unexpected death in avid dieters using the liquid-protein-modified-fast diet. Observations in 17 patients and the role of the prolonged QT interval. Circulation. 1979 Dec;60(6):1401–1412. doi: 10.1161/01.cir.60.6.1401. [DOI] [PubMed] [Google Scholar]
  11. Lew E. A., Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis. 1979;32(8):563–576. doi: 10.1016/0021-9681(79)90119-x. [DOI] [PubMed] [Google Scholar]
  12. Miller G. J., Miller N. E. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975 Jan 4;1(7897):16–19. doi: 10.1016/s0140-6736(75)92376-4. [DOI] [PubMed] [Google Scholar]
  13. Rabkin S. W., Mathewson F. A., Hsu P. H. Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: the Manitoba Study. Am J Cardiol. 1977 Mar;39(3):452–458. doi: 10.1016/s0002-9149(77)80104-5. [DOI] [PubMed] [Google Scholar]
  14. Rhoads G. G., Gulbrandsen C. L., Kagan A. Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men. N Engl J Med. 1976 Feb 5;294(6):293–298. doi: 10.1056/NEJM197602052940601. [DOI] [PubMed] [Google Scholar]
  15. Sorensen T. I., Sonne-Holm S. Mortality in extremely overweight young men. J Chronic Dis. 1977 Jun;30(6):359–367. doi: 10.1016/0021-9681(77)90030-3. [DOI] [PubMed] [Google Scholar]
  16. Vertes V., Genuth S. M., Hazelton I. M. Supplemented fasting as a large-scale outpatient program. JAMA. 1977 Nov 14;238(20):2151–2153. [PubMed] [Google Scholar]
  17. Warnick G. R., Albers J. J. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res. 1978 Jan;19(1):65–76. [PubMed] [Google Scholar]
  18. Williams P., Robinson D., Bailey A. High-density lipoprotein and coronary risk factors in normal men. Lancet. 1979 Jan;1(8107):72–75. doi: 10.1016/s0140-6736(79)90063-1. [DOI] [PubMed] [Google Scholar]
  19. Wilson D. E., Lees R. S. Metabolic relationships among the plasma lipoproteins. Reciprocal changes in the concentrations of very low and low density lipoproteins in man. J Clin Invest. 1972 May;51(5):1051–1057. doi: 10.1172/JCI106896. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES