Abstract
The standard double-isotope Schilling test was used to study vitamin B12 absorption in seven patients with obstructive jaundice and 10 with T-tube bile duct drainage after cholecystectomy and bile duct exploration. In three and five of these patients respectively absorption was impaired. In the second group six patients were restudied after removal of the T tube, and in each case absorption was improved. Similar results were obtained after bile duct ligation in rats. Bile exclusion produced a 50-60% reduction in renal and hepatic uptake of vitamin B12 from the intestinal lumen. The malabsorption was corrected by replacing bile. These studies suggest that bile plays a part in the normal absorption of vitamin B12.
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Selected References
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- Agzamkhodzhaev S. M., Verniaeva T. I., Volovoi V. L. Sostoianie kishechnoi absorbtsii vitamina B 12 pri mekhanicheskoi zheltukhe. Ter Arkh. 1972 May;44(5):54–57. [PubMed] [Google Scholar]
- Allen R. H., Seetharam B., Podell E., Alpers D. H. Effect of proteolytic enzymes on the binding of cobalamin to R protein and intrinsic factor. In vitro evidence that a failure to partially degrade R protein is responsible for cobalamin malabsorption in pancreatic insufficiency. J Clin Invest. 1978 Jan;61(1):47–54. doi: 10.1172/JCI108924. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Andersen K. J., Romslo I. Interaction of conjugated bile acids and detergents with a radiosorbent assay of vitamin B-12. Clin Chim Acta. 1977 Apr 15;76(2):219–222. doi: 10.1016/0009-8981(77)90099-7. [DOI] [PubMed] [Google Scholar]
- BOOTH C. C., CHANARIN I., ANDERSON B. B., MOLLIN D. L. The site of absorption and tissue distribution of orally administered 56Co-labelled vitamin B12 in the rat. Br J Haematol. 1957 Jul;3(3):253–261. doi: 10.1111/j.1365-2141.1957.tb05794.x. [DOI] [PubMed] [Google Scholar]
- BOOTH C. C., MOLLIN D. L. The site of absorption of vitamin B12 in man. Lancet. 1959 Jan 3;1(7062):18–21. doi: 10.1016/s0140-6736(59)90979-1. [DOI] [PubMed] [Google Scholar]
- BORGSTROEM B., LUNDH G., HOFMANN A. THE SITE OF ABSORPTION OF CONJUGATED BILE SALTS IN MAN. Gastroenterology. 1963 Aug;45:229–238. [PubMed] [Google Scholar]
- Boyer J. L., Bloomer J. R. Canalicular bile secretion in man. Studies utilizing the biliary clearance of (14C)mannitol. J Clin Invest. 1974 Oct;54(4):773–781. doi: 10.1172/JCI107817. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GRASBECK R., KANTERO I., SIURALA M. Influence of calcium ions on vitamin-B12 absorption in steatorrhoea and pernicious anaemia. Lancet. 1959 Jan 31;1(7066):234–234. doi: 10.1016/s0140-6736(59)90056-x. [DOI] [PubMed] [Google Scholar]
- MOERTEL C. G., SCUDAMORE H. H., OWEN C. A., Jr, BOLLMAN J. L. Site of absorption of Co60-labeled vitamin B12 in the male albino rat. Am J Physiol. 1960 Aug;199:289–291. doi: 10.1152/ajplegacy.1960.199.2.289. [DOI] [PubMed] [Google Scholar]
- Mackenzie I. L., Donaldson R. M., Jr Effect of divalent cations and pH on intrinsic factor-mediated attachment of vitamin B 12 to intestinal microvillous membranes. J Clin Invest. 1972 Sep;51(9):2465–2471. doi: 10.1172/JCI107060. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mathan V. I., Babior B. M., Donaldson R. M., Jr Kinetics of the attachment of intrinsic factor-bound cobamides to ileal receptors. J Clin Invest. 1974 Sep;54(3):598–608. doi: 10.1172/JCI107797. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schade S. G., Schilling R. F. Effect of pepsin on the absorption of food vitamin B12 and iron. Am J Clin Nutr. 1967 Jun;20(6):636–640. doi: 10.1093/ajcn/20.6.636. [DOI] [PubMed] [Google Scholar]