Abstract
The use of thyroxine replacement therapy was studied in 2710 patients with a previous diagnosis of either thyrotoxicosis or primary hypothyroidism. The patients, who were treated in five centres, were followed-up continuously using an automated register. Seventy per cent of patients had been prescribed daily doses of thyroxine of 200 microgram or more. The estimated 10-year cumulative incidence of detected undertreatment was 13 . 2% (95% confidence limits 10 . 9-15 .6%). The median cumulative incidence of recognised overtreatment was 6 . 2%. Improved patient education and the dissemination of guidelines to doctors on the use of thyroxine replacement may reduce the incidence of undertreatment or overtreatment.
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Selected References
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- Braverman L. E., Ingbar S. H., Sterling K. Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects. J Clin Invest. 1970 May;49(5):855–864. doi: 10.1172/JCI106304. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evered D., Young E. T., Ormston B. J., Menzies R., Smith P. A., Hall R. Treatment of hypothyroidism: a reappraisal of thyroxine therapy. Br Med J. 1973 Jul 21;3(5872):131–134. doi: 10.1136/bmj.3.5872.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haynes R. B., Sackett D. L., Taylor D. W., Roberts R. S., Johnson A. L. Manipulation of the therapeutic regimen to improve compliance: conceptions and misconceptions. Clin Pharmacol Ther. 1977 Aug;22(2):125–130. doi: 10.1002/cpt1977222125. [DOI] [PubMed] [Google Scholar]
- Hedley A. J., Flemming C. J., Chesters M. I., Michie W., Crooks J. Surgical treatment of thyrotoxicosis. Br Med J. 1970 Feb 28;1(5695):519–523. doi: 10.1136/bmj.1.5695.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hedley A. J., Scott A. M., Debenham G. A computer assisted follow-up register. Methods Inf Med. 1969 Apr;8(2):67–77. [PubMed] [Google Scholar]
- Hedley A. J., Scott A. M., Weir R. D., Crooks J. Computer-assisted follow-up register for the north-east of Scotland. Br Med J. 1970 Feb 28;1(5695):556–558. doi: 10.1136/bmj.1.5695.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jackson I. M., Cobb W. E. Why does anyone still use desiccated thyroid USP? Am J Med. 1978 Feb;64(2):284–288. doi: 10.1016/0002-9343(78)90057-8. [DOI] [PubMed] [Google Scholar]
- Nilsson G., Pettersson U., Levin K., Hughes R. Studies on replacement and suppressive dosages of 1-thyroxine. Acta Med Scand. 1977;202(4):257–260. doi: 10.1111/j.0954-6820.1977.tb16823.x. [DOI] [PubMed] [Google Scholar]
- Tunbridge W. M., Evered D. C., Hall R., Appleton D., Brewis M., Clark F., Evans J. G., Young E., Bird T., Smith P. A. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 1977 Dec;7(6):481–493. doi: 10.1111/j.1365-2265.1977.tb01340.x. [DOI] [PubMed] [Google Scholar]