Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1989 Jan;33(1):128–130. doi: 10.1128/aac.33.1.128

Ciprofloxacin for methicillin-resistant Staphylococcus aureus infections.

E A Piercy 1, D Barbaro 1, J P Luby 1, P A Mackowiak 1
PMCID: PMC171438  PMID: 2712546

Abstract

Thirty-seven patients with methicillin-resistant Staphylococcus aureus infections and/or colonization were treated with oral ciprofloxacin (750 mg twice a day). Clinical cure or improvement of infections occurred in 91% of the patients, and bacteriologic cure occurred in 60%. Ciprofloxacin therapy suppressed methicillin-resistant S. aureus colonization in 55% of the patients. Ciprofloxacin-resistant strains emerged in 6 of the 37 patients.

Full text

PDF
128

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aldridge K. E., Janney A., Sanders C. V. Comparison of the activities of coumermycin, ciprofloxacin, teicoplanin, and other non-beta-lactam antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus from various geographical locations. Antimicrob Agents Chemother. 1985 Nov;28(5):634–638. doi: 10.1128/aac.28.5.634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bacon A. E., Jorgensen K. A., Wilson K. H., Kauffman C. A. Emergence of nosocomial methicillin-resistant Staphylococcus aureus and therapy of colonized personnel during a hospital-wide outbreak. Infect Control. 1987 Apr;8(4):145–150. doi: 10.1017/s0195941700065802. [DOI] [PubMed] [Google Scholar]
  3. Bitar C. M., Mayhall C. G., Lamb V. A., Bradshaw T. J., Spadora A. C., Dalton H. P. Outbreak due to methicillin- and rifampin-resistant Staphylococcus aureus: epidemiology and eradication of the resistant strain from the hospital. Infect Control. 1987 Jan;8(1):15–23. doi: 10.1017/s0195941700066935. [DOI] [PubMed] [Google Scholar]
  4. Dacre J. E., Emmerson A. M., Jenner E. A. Nasal carriage of gentamicin and methicillin resistant Staphylococcus aureus treated with topical pseudomonic acid. Lancet. 1983 Oct 29;2(8357):1036–1036. doi: 10.1016/s0140-6736(83)91029-2. [DOI] [PubMed] [Google Scholar]
  5. Kado C. I., Liu S. T. Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol. 1981 Mar;145(3):1365–1373. doi: 10.1128/jb.145.3.1365-1373.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kelley S. G., Bertram M. A., Young L. S. Activity of ciprofloxacin against resistant clinical isolates. J Antimicrob Chemother. 1986 Mar;17(3):281–286. doi: 10.1093/jac/17.3.281. [DOI] [PubMed] [Google Scholar]
  7. Levine D. P., Cushing R. D., Jui J., Brown W. J. Community-acquired methicillin-resistant Staphylococcus aureus endocarditis in the Detroit Medical Center. Ann Intern Med. 1982 Sep;97(3):330–338. doi: 10.7326/0003-4819-97-3-330. [DOI] [PubMed] [Google Scholar]
  8. Locksley R. M., Cohen M. L., Quinn T. C., Tompkins L. S., Coyle M. B., Kirihara J. M., Counts G. W. Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection. Ann Intern Med. 1982 Sep;97(3):317–324. doi: 10.7326/0003-4819-97-3-317. [DOI] [PubMed] [Google Scholar]
  9. Mulligan M. E., Ruane P. J., Johnston L., Wong P., Wheelock J. P., MacDonald K., Reinhardt J. F., Johnson C. C., Statner B., Blomquist I. Ciprofloxacin for eradication of methicillin-resistant Staphylococcus aureus colonization. Am J Med. 1987 Apr 27;82(4A):215–219. [PubMed] [Google Scholar]
  10. Preheim L. C., Rimland D., Bittner M. J. Methicillin-resistant Staphylococcus aureus in Veterans Administration Medical Centers. Infect Control. 1987 May;8(5):191–194. doi: 10.1017/s0195941700065929. [DOI] [PubMed] [Google Scholar]
  11. Saravolatz L. D., Markowitz N., Arking L., Pohlod D., Fisher E. Methicillin-resistant Staphylococcus aureus. Epidemiologic observations during a community-acquired outbreak. Ann Intern Med. 1982 Jan;96(1):11–16. doi: 10.7326/0003-4819-96-1-11. [DOI] [PubMed] [Google Scholar]
  12. Smith S. M., Eng R. H., Berman E. The effect of ciprofloxacin on methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1986 Mar;17(3):287–295. doi: 10.1093/jac/17.3.287. [DOI] [PubMed] [Google Scholar]
  13. Standiford H. C. Methicillin-resistant Staphylococcus aureus infections: it's time to get tough. Infect Control. 1987 May;8(5):187–189. doi: 10.1017/s0195941700065917. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES