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. 1980 Oct 18;281(6247):1036–1038. doi: 10.1136/bmj.281.6247.1036

The neuropsychiatry of megaloblastic anaemia.

S D Shorvon, M W Carney, I Chanarin, E H Reynolds
PMCID: PMC1714413  PMID: 6253016

Abstract

The neuropsychiatric states of 50 patients with vitamin B12 deficiency and 34 patients with folate deficiency presenting with megaloblastosis in a general hospital were examined and compared. Abnormalities of the nervous system were found in two-thirds of both groups. Peripheral neuropathy was the most common condition associated with vitamin B12 deficiency and affective disorder with folate deficiency. The proportions of patients with organic mental change were similar in the two groups. Subacute combined degeneration of the cord was an uncommon complication and occurred only in the patients with vitamin B12 deficiency. There was no relation between haematological and neuropsychiatric abnormalities. The neuropsychiatry of megaloblastic anaemia seen in this study of patients presenting to haematologists or general physicians contrasts with that reported previously, before haematological techniques for separating the two deficiencies were introduced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Lockner D., Reizenstein P., Wennberg A., Widén L. Peripheral nerve function in pernicious anemia before and after treatment. Acta Haematol. 1969;41(5):257–263. doi: 10.1159/000208860. [DOI] [PubMed] [Google Scholar]
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