Abstract
Using agar dilution, we determined MICs of penicillin, cefoxitin, ceftriaxone, cefmetazole, tetracycline, and spectinomycin for 129 strains of Neisseria gonorrhoeae. All strains were susceptible to ceftriaxone (MIC range, less than or equal to 0.008 to 0.06 micrograms/ml) and spectinomycin (16 to 32 micrograms/ml). The MICs for 50, 90, and 100% of strains tested were 1.0, 2.0, and greater than 8.0 micrograms/ml; 0.12, 1.0, and greater than 8.0 micrograms/ml; 0.5, 1.0, and 2.0 micrograms/ml; and 1.0, 2.0, and greater than 8.0 micrograms/ml for cefmetazole, penicillin, cefoxitin, and tetracycline, respectively. Seven strains were beta-lactamase producers; eight were chromosomally resistant to penicillin. There was a log-linear relation for non-beta-lactamase-producing strains between the MICs of cefmetazole, cefoxitin, and tetracycline and the MIC of penicillin (Pearson r = 0.787, 0.544, and 0.358, respectively).
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berg S. W., Kilpatrick M. E., Harrison W. O., McCutchan J. A. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979 Sep 6;301(10):509–511. doi: 10.1056/NEJM197909063011001. [DOI] [PubMed] [Google Scholar]
- Dillon J. A., Tostowaryk W., Pauzé M. Effects of different media and methods of inoculum preparation on results of antimicrobial susceptibility testing of Neisseria gonorrhoeae by agar dilution. Antimicrob Agents Chemother. 1987 Nov;31(11):1744–1749. doi: 10.1128/aac.31.11.1744. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dougherty T. J. Genetic analysis and penicillin-binding protein alterations in Neisseria gonorrhoeae with chromosomally mediated resistance. Antimicrob Agents Chemother. 1986 Nov;30(5):649–652. doi: 10.1128/aac.30.5.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmes K. K., Karney W. W., Harnisch J. P., Wiesner P. J., Turck M., Pedersen A. H. Single-dose aqueous procaine penicillin G therapy for gonorrhea: use of probenecid and cause of treatment failure. J Infect Dis. 1973 Apr;127(4):455–460. doi: 10.1093/infdis/127.4.455. [DOI] [PubMed] [Google Scholar]
- Hook E. W., 3rd, Holmes K. K. Gonococcal infections. Ann Intern Med. 1985 Feb;102(2):229–243. doi: 10.7326/0003-4819-102-2-229. [DOI] [PubMed] [Google Scholar]
- Knapp J. S., Zenilman J. M., Biddle J. W., Perkins G. H., DeWitt W. E., Thomas M. L., Johnson S. R., Morse S. A. Frequency and distribution in the United States of strains of Neisseria gonorrhoeae with plasmid-mediated, high-level resistance to tetracycline. J Infect Dis. 1987 Apr;155(4):819–822. doi: 10.1093/infdis/155.4.819. [DOI] [PubMed] [Google Scholar]
- Maness M. J., Sparling P. F. Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae. J Infect Dis. 1973 Sep;128(3):321–330. doi: 10.1093/infdis/128.3.321. [DOI] [PubMed] [Google Scholar]
- Rajan V. S., Sng E. H., Thirumoorthy T., Goh C. L. Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1982 Oct;58(5):314–316. doi: 10.1136/sti.58.5.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rice R. J., Biddle J. W., JeanLouis Y. A., DeWitt W. E., Blount J. H., Morse S. A. Chromosomally mediated resistance in Neisseria gonorrhoeae in the United States: results of surveillance and reporting, 1983-1984. J Infect Dis. 1986 Feb;153(2):340–345. doi: 10.1093/infdis/153.2.340. [DOI] [PubMed] [Google Scholar]
- Zenilman J. M., Nims L. J., Menegus M. A., Nolte F., Knapp J. S. Spectinomycin-resistant gonococcal infections in the United States, 1985-1986. J Infect Dis. 1987 Dec;156(6):1002–1004. doi: 10.1093/infdis/156.6.1002. [DOI] [PubMed] [Google Scholar]