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. 1988 Mar;42(3):498–505.

Efficient computations in multilocus linkage analysis.

G M Lathrop 1, J M Lalouel 1
PMCID: PMC1715153  PMID: 3162348

Abstract

This paper describes efficient methods for likelihood calculations and maximum-likelihood estimation in multilocus linkage analysis of reference families and general disease pedigrees, and it documents their performance as implemented in the LINKAGE programs. This information should be of considerable value in determining computing needs for linkage investigations, and in evaluating the merits of alternative algorithms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker D., Wright E., Nguyen K., Cannon L., Fain P., Goldgar D., Bishop D. T., Carey J., Baty B., Kivlin J. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science. 1987 May 29;236(4805):1100–1102. doi: 10.1126/science.3107130. [DOI] [PubMed] [Google Scholar]
  2. Braverman M. S. An algorithm to improve the computational efficiency of genetic linkage analysis. Comput Biomed Res. 1985 Feb;18(1):24–36. doi: 10.1016/0010-4809(85)90004-7. [DOI] [PubMed] [Google Scholar]
  3. Clayton J. A multipoint linkage analysis program for X-linked disorders, with the example of Duchenne muscular dystrophy and seven DNA probes. Hum Genet. 1986 May;73(1):68–72. doi: 10.1007/BF00292667. [DOI] [PubMed] [Google Scholar]
  4. Drayna D., White R. The genetic linkage map of the human X chromosome. Science. 1985 Nov 15;230(4727):753–758. doi: 10.1126/science.4059909. [DOI] [PubMed] [Google Scholar]
  5. Elston R. C., Stewart J. A general model for the genetic analysis of pedigree data. Hum Hered. 1971;21(6):523–542. doi: 10.1159/000152448. [DOI] [PubMed] [Google Scholar]
  6. Gusella J. F., Wexler N. S., Conneally P. M., Naylor S. L., Anderson M. A., Tanzi R. E., Watkins P. C., Ottina K., Wallace M. R., Sakaguchi A. Y. A polymorphic DNA marker genetically linked to Huntington's disease. Nature. 1983 Nov 17;306(5940):234–238. doi: 10.1038/306234a0. [DOI] [PubMed] [Google Scholar]
  7. Lalouel J. M., Lathrop G. M., White R. Construction of human genetic linkage maps: II. Methodological issues. Cold Spring Harb Symp Quant Biol. 1986;51(Pt 1):39–47. doi: 10.1101/sqb.1986.051.01.006. [DOI] [PubMed] [Google Scholar]
  8. Lander E. S., Green P. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2363–2367. doi: 10.1073/pnas.84.8.2363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lange K., Boehnke M. Extensions to pedigree analysis. V. Optimal calculation of Mendelian likelihoods. Hum Hered. 1983;33(5):291–301. doi: 10.1159/000153393. [DOI] [PubMed] [Google Scholar]
  10. Lathrop G. M., Lalouel J. M. Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet. 1984 Mar;36(2):460–465. [PMC free article] [PubMed] [Google Scholar]
  11. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lathrop G. M., Lalouel J. M., White R. L. Construction of human linkage maps: likelihood calculations for multilocus linkage analysis. Genet Epidemiol. 1986;3(1):39–52. doi: 10.1002/gepi.1370030105. [DOI] [PubMed] [Google Scholar]
  13. Leppert M., Cavenee W., Callahan P., Holm T., O'Connell P., Thompson K., Lathrop G. M., Lalouel J. M., White R. A primary genetic map of chromosome 13q. Am J Hum Genet. 1986 Oct;39(4):425–437. [PMC free article] [PubMed] [Google Scholar]
  14. Morton N. E., MacLean C. J., Lew R., Yee S. Multipoint linkage analysis. Am J Hum Genet. 1986 Jun;38(6):868–883. [PMC free article] [PubMed] [Google Scholar]
  15. Ott J. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet. 1974 Sep;26(5):588–597. [PMC free article] [PubMed] [Google Scholar]
  16. Thompson E. A. Information gain in joint linkage analysis. IMA J Math Appl Med Biol. 1984;1(1):31–49. doi: 10.1093/imammb/1.1.31. [DOI] [PubMed] [Google Scholar]
  17. Wainwright B. J., Scambler P. J., Schmidtke J., Watson E. A., Law H. Y., Farrall M., Cooke H. J., Eiberg H., Williamson R. Localization of cystic fibrosis locus to human chromosome 7cen-q22. 1985 Nov 28-Dec 4Nature. 318(6044):384–385. doi: 10.1038/318384a0. [DOI] [PubMed] [Google Scholar]
  18. White R., Woodward S., Leppert M., O'Connell P., Hoff M., Herbst J., Lalouel J. M., Dean M., Vande Woude G. A closely linked genetic marker for cystic fibrosis. 1985 Nov 28-Dec 4Nature. 318(6044):382–384. doi: 10.1038/318382a0. [DOI] [PubMed] [Google Scholar]
  19. White R., Woodward S., Leppert M., O'Connell P., Hoff M., Herbst J., Lalouel J. M., Dean M., Vande Woude G. A closely linked genetic marker for cystic fibrosis. 1985 Nov 28-Dec 4Nature. 318(6044):382–384. doi: 10.1038/318382a0. [DOI] [PubMed] [Google Scholar]

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