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. 1988 Apr;42(4):560–564.

Chromosomal localization of the gene for a human thyroid hormone-binding protein.

N C Popescu 1, S Y Cheng 1, I Pastan 1
PMCID: PMC1715215  PMID: 2831713

Abstract

A cDNA for the gene that encodes for a human cellular thyroid hormone-binding protein (p55) has recently been isolated and sequenced. The sequence of p55 indicates that it is identical to the protein disulfide isomerase and the beta-subunit of prolyl 4-hydroxylase. By in situ hybridization, the gene for p55 was localized on chromosome 17 at band q25. This localization shows that the p55 gene is not linked to either erbA1 or erbA2; two other thyroid hormone-binding protein genes are located at 17q 11-21 and 3p21-pter, respectively. The localization of p55 gene will permit the evaluation of the possible effects of chromosome changes on the structure and activity of the p55 gene in chromosome syndromes or neoplasms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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