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. 1988 Jan;42(1):125–131.

A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene.

M R Hayden 1, J Hewitt 1, J J Wasmuth 1, J J Kastelein 1, S Langlois 1, M Conneally 1, J Haines 1, B Smith 1, C Hilbert 1, D Allard 1
PMCID: PMC1715326  PMID: 2892395

Abstract

A polymorphic marker (D4S62) that is genetically closely linked to D4S10 and is in the region of the gene for Huntington disease is described. A four-allele polymorphism is detected when HincII-digested DNA is hybridized with D4S62. D4S62 maps, by Southern blot analysis using somatic-cell hybrids, to 4p16.1 closer to the centromere than does D4S10. The use of the polymorphisms detected by D4S62 increases the informativeness of markers close to the gene for Huntington disease and will be useful for preclinical diagnosis. D4S62 detects transcripts of approximately 6,000 nucleotides in rat, mouse, and monkey liver and brain. This represents the first demonstration of conserved expressed sequences close to the gene for Huntington disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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