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. 1988 Jan;42(1):84–88.

Linkage studies in a new X-linked myopathy, suggesting exclusion of DMD locus and tentative assignment to distal Xq.

P Saviranta 1, M Lindlöf 1, A E Lehesjoki 1, H Kalimo 1, H Lang 1, V Sonninen 1, M L Savontaus 1, A de la Chapelle 1
PMCID: PMC1715330  PMID: 2892402

Abstract

We here report linkage studies in a family suffering from a recently described hereditary muscle disease named X-linked myopathy with excessive autophagy (XMEA). Significant lod scores excluding linkage to the Duchenne-Becker muscular dystrophy locus were found. Several other loci on the short and long arms of the X chromosome produced negative lod scores, whereas probe DX13-7 defining locus DXS15 showed no recombinants and a lod score of z = 0.903 at theta = .0. Further studies should be done to determine whether the gene for XMEA is (1) located at Xq and (2) caused by a mutation of the Emery-Dreifuss muscular dystrophy gene, which has been assigned to the same region.

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Selected References

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