Abstract
Dupuytren contracture is a connective tissue disease mainly confined to Caucasians. It is characterized by nodular growth and proliferation of collagen in the palmar and plantar fascias. Autosomal dominance with variable penetrance is considered the most likely mode of inheritance. The goal of the present study was to examine the cytogenetics of this common benign neoplasia. Chromosome studies were performed on the nodular growth of eight patients with Dupuytren contracture, all of whom showed chromosome abnormalities that included numerical and structural clones, random numerical and structural aberrations, prophasing, and premature centromere separation. Numerical clones of trisomies 7 and/or 8, as well as some random structural aberrations, were considered to represent in vivo abnormalities, whereas most structural clones appeared likely to be the results of rapid and selective in vitro growth of particular cells. The disease process occurring in Dupuytren contracture was found to involve marked chromosome instability, as well as some in vivo clonal formation. Transverse fascial tissue, usually considered to be uninvolved in the disease process, unexpectedly showed all the same types of abnormalities as the nodular tissue. This indicates a more widespread distribution of disease in the tissues than previously suspected. The findings in the present study are similar to those in various malignant and benign types of tumorous growth and suggest the importance of further cytogenetic investigation into other conditions of benign growth.
Full text
PDF







Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barker D., Wright E., Nguyen K., Cannon L., Fain P., Goldgar D., Bishop D. T., Carey J., Baty B., Kivlin J. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science. 1987 May 29;236(4805):1100–1102. doi: 10.1126/science.3107130. [DOI] [PubMed] [Google Scholar]
- Berger R., Bloomfield C. D., Sutherland G. R. Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites. Cytogenet Cell Genet. 1985;40(1-4):490–535. doi: 10.1159/000132181. [DOI] [PubMed] [Google Scholar]
- Bowser-Riley S., Bain A. D., Noble J., Lamb D. W. Chromosome abnormalities in Dupuytren's disease. Lancet. 1975 Dec 27;2(7948):1282–1283. doi: 10.1016/s0140-6736(75)90614-5. [DOI] [PubMed] [Google Scholar]
- Brickley-Parsons D., Glimcher M. J., Smith R. J., Albin R., Adams J. P. Biochemical changes in the collagen of the palmar fascia in patients with Dupuytren's disease. J Bone Joint Surg Am. 1981 Jun;63(5):787–797. [PubMed] [Google Scholar]
- Emanuel B. S., Cannizzaro L. A., Seyer J. M., Myers J. C. Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2. Proc Natl Acad Sci U S A. 1985 May;82(10):3385–3389. doi: 10.1073/pnas.82.10.3385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gelberman R. H., Amiel D., Rudolph R. M., Vance R. M. Dupuytren's contracture. An electron microscopic, biochemical, and clinical correlative study. J Bone Joint Surg Am. 1980 Apr;62(3):425–432. [PubMed] [Google Scholar]
- Hunter J. A., Ogdon C., Norris M. G. Dupuytren's contracture. I--Chemical pathology. Br J Plast Surg. 1975 Jan;28(1):10–18. doi: 10.1016/s0007-1226(75)90144-7. [DOI] [PubMed] [Google Scholar]
- Mark J., Dahlenfors R. Cytogenetical observations in 100 human benign pleomorphic adenomas: specificity of the chromosomal aberrations and their relationship to sites of localized oncogenes. Anticancer Res. 1986 Mar-Apr;6(2):299–308. [PubMed] [Google Scholar]
- Obe G., Göbel D., Engeln H., Herha J., Natarajan A. T. Chromosomal aberrations in peripheral lymphocytes of alcoholics. Mutat Res. 1980 Dec;73(2):377–386. doi: 10.1016/0027-5107(80)90202-x. [DOI] [PubMed] [Google Scholar]
- Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971 Oct 30;2(7731):971–972. doi: 10.1016/s0140-6736(71)90287-x. [DOI] [PubMed] [Google Scholar]
- Sergovich F. R., Botz J. S., McFarlane R. M. Nonrandom cytogenetic abnormalities in Dupuytren's disease. N Engl J Med. 1983 Jan 20;308(3):162–163. [PubMed] [Google Scholar]