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. 1989 Feb;44(2):282–287.

Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers

François Leduc, Hiltrud Brauch, Camile Hajj, Alexander Dobrovic, Frederick Kaye, Adi Gazdar, J William Harbour, Olive S Pettengill, George D Sorenson, A van den Berg, K Kok, Barbara Campling, François Paquin, W E C Bradley, Berton Zbar, John Minna, Charles Buys, Joseph Ayoub
PMCID: PMC1715394  PMID: 2536219

Abstract

The ERBAβ gene codes for a DNA-binding thyroid hormone receptor (THR) and maps to chromosome 3p21-p25, overlapping a 3p deletion characterizing small-cell lung carcinoma (SCLC). A DNA clone detecting an RFLP at the ERBAβ locus has been used to probe a large number of lung .tumors. Virtually all SCLC had lost heterozygosity, showing that the 3p deletion in SCLC includes this gene. A substantial but smaller proportion of non-small-cell carcinomas had lost heterozygosity at ERBAβ. Among all non-small-cell tumors some had lost heterozygosity at the proximal locus DNF15S2 (band 3p21) but not at ERBAβ, whereas none were found where the reverse was true. Therefore, the locus which plays a role in non-small-cell tumorigenesis probably lies closer to DNF15S2 than to ERBAβ and is almost certainly not the latter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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