Abstract
The distribution of the immunoglobulin kappa light-chain determinant, Km1, was examined in 52 patients with alopecia areata, 22 of whom possessed serum antibodies to thyroid antigens. The allotype frequency was significantly higher than that found in a referent population of 105 healthy subjects. Furthermore, it was determined that within the patient population, the Km1 allotype was associated with the absence of detectable serum autoantibodies. In such patients, this association may be due to linkage disequilibrium between the chromosome 2 gene coding for Km1 and a chromosome 2 gene coding for susceptibility to alopecia areata.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Galbraith G. M., Thiers B. H., Pandey J. P. Gm allotype associated resistance and susceptibility to alopecia areata. Clin Exp Immunol. 1984 Apr;56(1):149–152. [PMC free article] [PubMed] [Google Scholar]
- Galbraith G. M., Thiers B. H., Vasily D. B., Fudenberg H. H. Immunological profiles in alopecia areata. Br J Dermatol. 1984 Feb;110(2):163–170. doi: 10.1111/j.1365-2133.1984.tb07462.x. [DOI] [PubMed] [Google Scholar]
- Granoff D. M., Pandey J. P., Boies E., Squires J., Munson R. S., Jr, Suarez B. Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype. J Clin Invest. 1984 Nov;74(5):1708–1714. doi: 10.1172/JCI111588. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Green A. The epidemiologic approach to studies of association between HLA and disease. II. Estimation of absolute risks, etiologic and preventive fraction. Tissue Antigens. 1982 Apr;19(4):259–268. doi: 10.1111/j.1399-0039.1982.tb01450.x. [DOI] [PubMed] [Google Scholar]
- Pandey J. P., Shannon B. T., Arala-Chaves M. P., Fudenberg H. H. Gm and Km frequencies in a Portuguese population. Hum Genet. 1982;61(2):154–156. doi: 10.1007/BF00274207. [DOI] [PubMed] [Google Scholar]
- Pandey J. P., Zollinger W. D., Fudenberg H. H., Loadholt C. B. Immunoglobulin allotypes and immune response to meningococcal group B polysaccharide. J Clin Invest. 1981 Nov;68(5):1378–1380. doi: 10.1172/JCI110387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Svejgaard A., Nielsen L. S., Svejgaard E., Nielsen F. K., Hjortshoj A., Zachariae H. HL-A in psoriasis vulgaris and in pustular psoriasis--population and family studies. Br J Dermatol. 1974 Aug;91(2):145–153. doi: 10.1111/j.1365-2133.1974.tb15859.x. [DOI] [PubMed] [Google Scholar]
- Whittingham S., Propert D. N. Gm and Km allotypes, immune response and disease susceptibility. Monogr Allergy. 1986;19:52–70. [PubMed] [Google Scholar]
- Whittingham S., Propert D. N., Mackay I. R. A strong association between the antinuclear antibody anti-La (SS-B) and the kappa chain allotype Km(1). Immunogenetics. 1984;19(4):295–299. doi: 10.1007/BF00345402. [DOI] [PubMed] [Google Scholar]