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. 1980 Dec 20;281(6256):1676–1678. doi: 10.1136/bmj.281.6256.1676

A polymorphism of the ability to smell urinary metabolites of asparagus.

M Lison, S H Blondheim, R N Melmed
PMCID: PMC1715705  PMID: 7448566

Abstract

The urinary excretion of (an) odorous substance(s) after eating asparagus is not an inborn error of metabolism as has been supposed. The detection of the odour constitutes a specific smell hypersensitivity. Those who could smell the odour in their own urine could all smell it in the urine of anyone who had eaten asparagus, whether or not that person was able to smell it himself. Thresholds for detecting the odour appeared to be bimodal in distribution, with 10% of 307 subjects tested able to smell it at high dilutions, suggesting a genetically determined specific hypersensitivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON A. C., MCWHIRTER K. G. Two unifactorial characters for which man is polymorphic. Nature. 1956 Oct 6;178(4536):748–749. doi: 10.1038/178748c0. [DOI] [PubMed] [Google Scholar]
  2. Amoore J. E. Specific anosmia: a clue to the olfactory code. Nature. 1967 Jun 10;214(5093):1095–1098. doi: 10.1038/2141095a0. [DOI] [PubMed] [Google Scholar]
  3. Campanella G., Filla A., De Michele G. Smell and taste acuity in epileptic syndromes. Eur Neurol. 1978;17(3):136–141. doi: 10.1159/000114936. [DOI] [PubMed] [Google Scholar]
  4. Gearhart H. L., Pierce S. K., Payne-Bose D. Volatile organic components in human urine after ingestion of asparagus. Clin Chem. 1977 Oct;23(10):1941–1941. [PubMed] [Google Scholar]
  5. HENKIN R. I., POWELL G. F. Increased sensitivity of taste and smell in cystic fibrosis. Science. 1962 Dec 7;138(3545):1107–1108. doi: 10.1126/science.138.3545.1107. [DOI] [PubMed] [Google Scholar]
  6. Henkin R. I., Bartter F. C. Studies on olfactory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration. J Clin Invest. 1966 Oct;45(10):1631–1639. doi: 10.1172/JCI105470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. White R. H. Occurrence of S-methyl thioesters in urines of humans after they have eaten asparagus. Science. 1975 Sep 5;189(4205):810–811. doi: 10.1126/science.1162354. [DOI] [PubMed] [Google Scholar]

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