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. 1990 Feb;34(2):349–354. doi: 10.1128/aac.34.2.349

In vitro investigation of BK-218, a new oral and parenteral cephalosporin.

I Szabó 1, J Barabás 1, A Tar 1, L Kiss 1, M Filep 1, T Schmidt 1, K Marossy 1, B Tóth-Martinez 1, G Barabás 1, F Hernádi 1
PMCID: PMC171585  PMID: 2109582

Abstract

The antibacterial activity of BK-218 was similar to that of cefamandole when it was tested against several laboratory strains. The inhibiting effect of BK-218 was greater than that of cephalexin and cefoxitin on penicillin-binding proteins of Escherichia coli HB101. This result was in close correlation with the relative inhibition of radiolabeled glucosamine incorporation (greatest with BK-218) and with the lytic effect (most intensive with BK-218). BK-218 proved to be a good inhibitor for all five of the beta-lactamases that were investigated, although two enzymes (Enterobacter cloacae P99 and Pseudomonas aeruginosa Cilote) hydrolyzed it to some extent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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