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. 1997 Aug;61(2):354–362. doi: 10.1086/514843

Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region.

R Arngrímsson 1, C Hayward 1, S Nadaud 1, A Baldursdóttir 1, J J Walker 1, W A Liston 1, R I Bjarnadóttir 1, D J Brock 1, R T Geirsson 1, J M Connor 1, F Soubrier 1
PMCID: PMC1715904  PMID: 9311740

Abstract

Pregnancy-induced hypertension may be regarded as a manifestation of endothelial-cell dysfunction. The role of the eNOS gene in the development of a familial pregnancy-induced hypertension was evaluated by analysis of linkage among affected sisters and in multiplex families (n = 50). Markers from a 4-cM region encoding the eNOS gene showed distortion from the expected allele sharing among affected sisters (P = .001-.05), and the statistic obtained from the multilocus application of the affected-pedigree-member method also showed distortion (T[f(P)=sqrt(P)] = 3.53; P < .001). A LOD score of 3.36 was obtained for D7S505 when a best-fitting model derived from genetic epidemiological data was used, and LOD scores of 2.54-4.03 were obtained when various other genetic models were used. Estimates of recombination rate, rather than maximum LOD-score values, were affected by changes in the genetic parameters. The transmission-disequilibrium test, a model-free estimate of linkage, showed strongest association and linkage with a microsatellite within intron 13 of the eNOS gene (P = .005). These results support the localization of a familial pregnancy-induced hypertension-susceptibility locus in the region of chromosome 7q36 encoding the eNOS gene.

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Selected References

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