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. 1997 Dec;61(6):1450–1454. doi: 10.1086/301634

Identification of an interstitial deletion in an adult female with schizophrenia, mental retardation, and dysmorphic features: further support for a putative schizophrenia-susceptibility locus at 5q21-23.1.

R L Bennett, M Karayiorgou, C A Sobin, T H Norwood, M A Kay
PMCID: PMC1716062  PMID: 9399892

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bassett A. S. Chromosomal aberrations and schizophrenia. Autosomes. Br J Psychiatry. 1992 Sep;161:323–334. doi: 10.1192/bjp.161.3.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bassett A. S., McGillivray B. C., Jones B. D., Pantzar J. T. Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet. 1988 Apr 9;1(8589):799–801. doi: 10.1016/s0140-6736(88)91660-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Driscoll D. A., Salvin J., Sellinger B., Budarf M. L., McDonald-McGinn D. M., Zackai E. H., Emanuel B. S. Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis. J Med Genet. 1993 Oct;30(10):813–817. doi: 10.1136/jmg.30.10.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gottesman I. I., Shields J. A polygenic theory of schizophrenia. Proc Natl Acad Sci U S A. 1967 Jul;58(1):199–205. doi: 10.1073/pnas.58.1.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Karayiorgou M., Gogos J. A. Dissecting the genetic complexity of schizophrenia. Mol Psychiatry. 1997 May;2(3):211–223. doi: 10.1038/sj.mp.4000271. [DOI] [PubMed] [Google Scholar]
  6. Karayiorgou M., Morris M. A., Morrow B., Shprintzen R. J., Goldberg R., Borrow J., Gos A., Nestadt G., Wolyniec P. S., Lasseter V. K. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7612–7616. doi: 10.1073/pnas.92.17.7612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kendler K. S., Diehl S. R. The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr Bull. 1993;19(2):261–285. doi: 10.1093/schbul/19.2.261. [DOI] [PubMed] [Google Scholar]
  8. Kendler K. S., McGuire M., Gruenberg A. M., O'Hare A., Spellman M., Walsh D. The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry. 1993 Jul;50(7):527–540. doi: 10.1001/archpsyc.1993.01820190029004. [DOI] [PubMed] [Google Scholar]
  9. Marsh D. G., Neely J. D., Breazeale D. R., Ghosh B., Freidhoff L. R., Ehrlich-Kautzky E., Schou C., Krishnaswamy G., Beaty T. H. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science. 1994 May 20;264(5162):1152–1156. doi: 10.1126/science.8178175. [DOI] [PubMed] [Google Scholar]
  10. Murray R. M., Reveley A. M., McGuffin P. Genetic vulnerability to schizophrenia. Psychiatr Clin North Am. 1986 Mar;9(1):3–16. [PubMed] [Google Scholar]
  11. Pulver A. E., Nestadt G., Goldberg R., Shprintzen R. J., Lamacz M., Wolyniec P. S., Morrow B., Karayiorgou M., Antonarakis S. E., Housman D. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis. 1994 Aug;182(8):476–478. doi: 10.1097/00005053-199408000-00010. [DOI] [PubMed] [Google Scholar]
  12. Schwab S. G., Eckstein G. N., Hallmayer J., Lerer B., Albus M., Borrmann M., Lichtermann D., Ertl M. A., Maier W., Wildenauer D. B. Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Mol Psychiatry. 1997 Mar;2(2):156–160. doi: 10.1038/sj.mp.4000263. [DOI] [PubMed] [Google Scholar]
  13. St Clair D., Blackwood D., Muir W., Carothers A., Walker M., Spowart G., Gosden C., Evans H. J. Association within a family of a balanced autosomal translocation with major mental illness. Lancet. 1990 Jul 7;336(8706):13–16. doi: 10.1016/0140-6736(90)91520-k. [DOI] [PubMed] [Google Scholar]
  14. Straub R. E., MacLean C. J., O'Neill F. A., Walsh D., Kendler K. S. Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatry. 1997 Mar;2(2):148–155. doi: 10.1038/sj.mp.4000258. [DOI] [PubMed] [Google Scholar]

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