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. 1997 Jun;60(6):1283–1288. doi: 10.1086/515482

Understanding the genetic basis of mood disorders: where do we stand?

V I Reus 1, N B Freimer 1
PMCID: PMC1716132  PMID: 9199547

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baron M., Freimer N. F., Risch N., Lerer B., Alexander J. R., Straub R. E., Asokan S., Das K., Peterson A., Amos J. Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nat Genet. 1993 Jan;3(1):49–55. doi: 10.1038/ng0193-49. [DOI] [PubMed] [Google Scholar]
  2. Baron M., Risch N., Hamburger R., Mandel B., Kushner S., Newman M., Drumer D., Belmaker R. H. Genetic linkage between X-chromosome markers and bipolar affective illness. Nature. 1987 Mar 19;326(6110):289–292. doi: 10.1038/326289a0. [DOI] [PubMed] [Google Scholar]
  3. Berrettini W. H., Ferraro T. N., Goldin L. R., Weeks D. E., Detera-Wadleigh S., Nurnberger J. I., Jr, Gershon E. S. Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5918–5921. doi: 10.1073/pnas.91.13.5918. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bertelsen A., Harvald B., Hauge M. A Danish twin study of manic-depressive disorders. Br J Psychiatry. 1977 Apr;130:330–351. doi: 10.1192/bjp.130.4.330. [DOI] [PubMed] [Google Scholar]
  5. Blacker D., Faraone S. V., Rosen A. E., Guroff J. J., Adams P., Weissman M. M., Gershon E. S. Unipolar relatives in bipolar pedigrees: a search for elusive indicators of underlying bipolarity. Am J Med Genet. 1996 Sep 20;67(5):445–454. doi: 10.1002/(SICI)1096-8628(19960920)67:5<445::AID-AJMG2>3.0.CO;2-J. [DOI] [PubMed] [Google Scholar]
  6. Blackwood D. H., He L., Morris S. W., McLean A., Whitton C., Thomson M., Walker M. T., Woodburn K., Sharp C. M., Wright A. F. A locus for bipolar affective disorder on chromosome 4p. Nat Genet. 1996 Apr;12(4):427–430. doi: 10.1038/ng0496-427. [DOI] [PubMed] [Google Scholar]
  7. Breier A., Charney D. S., Heninger G. R. Major depression in patients with agoraphobia and panic disorder. Arch Gen Psychiatry. 1984 Dec;41(12):1129–1135. doi: 10.1001/archpsyc.1984.01790230015002. [DOI] [PubMed] [Google Scholar]
  8. Coryell W., Endicott J., Andreasen N. C., Keller M. B., Clayton P. J., Hirschfeld R. M., Scheftner W. A., Winokur G. Depression and panic attacks: the significance of overlap as reflected in follow-up and family study data. Am J Psychiatry. 1988 Mar;145(3):293–300. doi: 10.1176/ajp.145.3.293. [DOI] [PubMed] [Google Scholar]
  9. Davies J. L., Kawaguchi Y., Bennett S. T., Copeman J. B., Cordell H. J., Pritchard L. E., Reed P. W., Gough S. C., Jenkins S. C., Palmer S. M. A genome-wide search for human type 1 diabetes susceptibility genes. Nature. 1994 Sep 8;371(6493):130–136. doi: 10.1038/371130a0. [DOI] [PubMed] [Google Scholar]
  10. Ebers G. C., Kukay K., Bulman D. E., Sadovnick A. D., Rice G., Anderson C., Armstrong H., Cousin K., Bell R. B., Hader W. A full genome search in multiple sclerosis. Nat Genet. 1996 Aug;13(4):472–476. doi: 10.1038/ng0896-472. [DOI] [PubMed] [Google Scholar]
  11. Egeland J. A., Gerhard D. S., Pauls D. L., Sussex J. N., Kidd K. K., Allen C. R., Hostetter A. M., Housman D. E. Bipolar affective disorders linked to DNA markers on chromosome 11. 1987 Feb 26-Mar 4Nature. 325(6107):783–787. doi: 10.1038/325783a0. [DOI] [PubMed] [Google Scholar]
  12. Ewald H., Mors O., Flint T., Koed K., Eiberg H., Kruse T. A. A possible locus for manic depressive illness on chromosome 16p13. Psychiatr Genet. 1995 Summer;5(2):71–81. doi: 10.1097/00041444-199522000-00005. [DOI] [PubMed] [Google Scholar]
  13. Freimer N. B., Reus V. I., Escamilla M. A., McInnes L. A., Spesny M., Leon P., Service S. K., Smith L. B., Silva S., Rojas E. Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nat Genet. 1996 Apr;12(4):436–441. doi: 10.1038/ng0496-436. [DOI] [PubMed] [Google Scholar]
  14. Ginns E. I., Ott J., Egeland J. A., Allen C. R., Fann C. S., Pauls D. L., Weissenbachoff J., Carulli J. P., Falls K. M., Keith T. P. A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet. 1996 Apr;12(4):431–435. doi: 10.1038/ng0496-431. [DOI] [PubMed] [Google Scholar]
  15. Haines J. L., Ter-Minassian M., Bazyk A., Gusella J. F., Kim D. J., Terwedow H., Pericak-Vance M. A., Rimmler J. B., Haynes C. S., Roses A. D. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat Genet. 1996 Aug;13(4):469–471. doi: 10.1038/ng0896-469. [DOI] [PubMed] [Google Scholar]
  16. Hashimoto L., Habita C., Beressi J. P., Delepine M., Besse C., Cambon-Thomsen A., Deschamps I., Rotter J. I., Djoulah S., James M. R. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature. 1994 Sep 8;371(6493):161–164. doi: 10.1038/371161a0. [DOI] [PubMed] [Google Scholar]
  17. Jamison K. R., McInnis M. G. Genetic studies of manic-depressive illness. Nat Med. 1996 May;2(5):521–522. doi: 10.1038/nm0596-521. [DOI] [PubMed] [Google Scholar]
  18. Kelsoe J. R., Ginns E. I., Egeland J. A., Gerhard D. S., Goldstein A. M., Bale S. J., Pauls D. L., Long R. T., Kidd K. K., Conte G. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature. 1989 Nov 16;342(6247):238–243. doi: 10.1038/342238a0. [DOI] [PubMed] [Google Scholar]
  19. Kelsoe J. R., Sadovnick A. D., Kristbjarnarson H., Bergesch P., Mroczkowski-Parker Z., Drennan M., Rapaport M. H., Flodman P., Spence M. A., Remick R. A. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet. 1996 Nov 22;67(6):533–540. doi: 10.1002/(SICI)1096-8628(19961122)67:6<533::AID-AJMG4>3.0.CO;2-I. [DOI] [PubMed] [Google Scholar]
  20. Kendler K. S., Heath A. C., Martin N. G., Eaves L. J. Symptoms of anxiety and symptoms of depression. Same genes, different environments? Arch Gen Psychiatry. 1987 May;44(5):451–457. doi: 10.1001/archpsyc.1987.01800170073010. [DOI] [PubMed] [Google Scholar]
  21. Kuokkanen S., Sundvall M., Terwilliger J. D., Tienari P. J., Wikström J., Holmdahl R., Pettersson U., Peltonen L. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nat Genet. 1996 Aug;13(4):477–480. doi: 10.1038/ng0896-477. [DOI] [PubMed] [Google Scholar]
  22. McInnes L. A., Freimer N. B. Mapping genes for psychiatric disorders and behavioral traits. Curr Opin Genet Dev. 1995 Jun;5(3):376–381. doi: 10.1016/0959-437x(95)80054-9. [DOI] [PubMed] [Google Scholar]
  23. Morell V. Manic-depression findings spark polarized debate. Science. 1996 Apr 5;272(5258):31–32. doi: 10.1126/science.272.5258.31. [DOI] [PubMed] [Google Scholar]
  24. Pauls D. L., Bailey J. N., Carter A. S., Allen C. R., Egeland J. A. Complex segregation analyses of old order Amish families ascertained through bipolar I individuals. Am J Med Genet. 1995 Aug 14;60(4):290–297. doi: 10.1002/ajmg.1320600406. [DOI] [PubMed] [Google Scholar]
  25. Risch N., Botstein D. A manic depressive history. Nat Genet. 1996 Apr;12(4):351–353. doi: 10.1038/ng0496-351. [DOI] [PubMed] [Google Scholar]
  26. Sawcer S., Jones H. B., Feakes R., Gray J., Smaldon N., Chataway J., Robertson N., Clayton D., Goodfellow P. N., Compston A. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet. 1996 Aug;13(4):464–468. doi: 10.1038/ng0896-464. [DOI] [PubMed] [Google Scholar]
  27. Sherman S. L., DeFries J. C., Gottesman I. I., Loehlin J. C., Meyer J. M., Pelias M. Z., Rice J., Waldman I. Behavioral genetics '97: ASHG statement. Recent developments in human behavioral genetics: past accomplishments and future directions. Am J Hum Genet. 1997 Jun;60(6):1265–1275. doi: 10.1086/515473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Silverman G. A., Overhauser J., Gerken S., Aburomia R., O'Connell P., Krauter K. S., Detera-Wadleigh S. D., Yoshikawa T., Collins A. R., Geurts van Kessel A. Report of the Fourth International Workshop on Human Chromosome 18 Mapping. Boston, Massachusetts, October 7-9, 1996. Cytogenet Cell Genet. 1996;75(2-3):111–131. doi: 10.1159/000134462. [DOI] [PubMed] [Google Scholar]
  29. Smith L. B., Sapers B., Reus V. I., Freimer N. B. Attitudes towards bipolar disorder and predictive genetic testing among patients and providers. J Med Genet. 1996 Jul;33(7):544–549. doi: 10.1136/jmg.33.7.544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Spence M. A., Flodman P. L., Sadovnick A. D., Bailey-Wilson J. E., Ameli H., Remick R. A. Bipolar disorder: evidence for a major locus. Am J Med Genet. 1995 Oct 9;60(5):370–376. doi: 10.1002/ajmg.1320600505. [DOI] [PubMed] [Google Scholar]
  31. Stine O. C., Xu J., Koskela R., McMahon F. J., Gschwend M., Friddle C., Clark C. D., McInnis M. G., Simpson S. G., Breschel T. S. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet. 1995 Dec;57(6):1384–1394. [PMC free article] [PubMed] [Google Scholar]
  32. Straub R. E., Lehner T., Luo Y., Loth J. E., Shao W., Sharpe L., Alexander J. R., Das K., Simon R., Fieve R. R. A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nat Genet. 1994 Nov;8(3):291–296. doi: 10.1038/ng1194-291. [DOI] [PubMed] [Google Scholar]
  33. Weissman M. M., Gershon E. S., Kidd K. K., Prusoff B. A., Leckman J. F., Dibble E., Hamovit J., Thompson W. D., Pauls D. L., Guroff J. J. Psychiatric disorders in the relatives of probands with affective disorders. The Yale University--National Institute of Mental Health Collaborative Study. Arch Gen Psychiatry. 1984 Jan;41(1):13–21. doi: 10.1001/archpsyc.1984.01790120015003. [DOI] [PubMed] [Google Scholar]

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