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. 1990 Mar;34(3):476–478. doi: 10.1128/aac.34.3.476

Characterization of the Tet M determinants in urogenital and respiratory bacteria.

M C Roberts 1
PMCID: PMC171619  PMID: 2159259

Abstract

Tetracycline-resistant Fusobacterium nucleatum, Haemophilus ducreyi, Mycoplasma hominis, Peptostreptococcus spp., Ureaplasma urealyticum, and Veillonella parvula had DNA sequences which showed homology throughout the length of the Tet M transposon, Tn916. In contrast, Gardnerella vaginalis, commensal Neisseria spp., and the 25.2-megadalton plasmid family lacked the complete transposon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. T., Roberts M. C. Cloning and characterization of tetM gene from a Ureaplasma urealyticum strain. Antimicrob Agents Chemother. 1987 Nov;31(11):1852–1854. doi: 10.1128/aac.31.11.1852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burdett V., Inamine J., Rajagopalan S. Heterogeneity of tetracycline resistance determinants in Streptococcus. J Bacteriol. 1982 Mar;149(3):995–1004. doi: 10.1128/jb.149.3.995-1004.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chen S. T., Clowes R. C. Nucleotide sequence comparisons of plasmids pHD131, pJB1, pFA3, and pFA7 and beta-lactamase expression in Escherichia coli, Haemophilus influenzae, and Neisseria gonorrhoeae. J Bacteriol. 1987 Jul;169(7):3124–3130. doi: 10.1128/jb.169.7.3124-3130.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clewell D. B., Flannagan S. E., Ike Y., Jones J. M., Gawron-Burke C. Sequence analysis of termini of conjugative transposon Tn916. J Bacteriol. 1988 Jul;170(7):3046–3052. doi: 10.1128/jb.170.7.3046-3052.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clewell D. B., Gawron-Burke C. Conjugative transposons and the dissemination of antibiotic resistance in streptococci. Annu Rev Microbiol. 1986;40:635–659. doi: 10.1146/annurev.mi.40.100186.003223. [DOI] [PubMed] [Google Scholar]
  6. Fayet O., Froment Y., Piffaretti J. C. Beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae have retained an intact right part of a Tn3-like transposon. J Bacteriol. 1982 Jan;149(1):136–144. doi: 10.1128/jb.149.1.136-144.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heffron F., Rubens C., Falkow S. Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: identity of laboratory-constructed plasmids and clinical isolates. J Bacteriol. 1977 Jan;129(1):530–533. doi: 10.1128/jb.129.1.530-533.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hächler H., Kayser F. H., Berger-Bächi B. Homology of a transferable tetracycline resistance determinant of Clostridium difficile with Streptococcus (Enterococcus) faecalis transposon Tn916. Antimicrob Agents Chemother. 1987 Jul;31(7):1033–1038. doi: 10.1128/aac.31.7.1033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jones J. M., Yost S. C., Pattee P. A. Transfer of the conjugal tetracycline resistance transposon Tn916 from Streptococcus faecalis to Staphylococcus aureus and identification of some insertion sites in the staphylococcal chromosome. J Bacteriol. 1987 May;169(5):2121–2131. doi: 10.1128/jb.169.5.2121-2131.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Knapp J. S., Johnson S. R., Zenilman J. M., Roberts M. C., Morse S. A. High-level tetracycline resistance resulting from TetM in strains of Neisseria spp., Kingella denitrificans, and Eikenella corrodens. Antimicrob Agents Chemother. 1988 May;32(5):765–767. doi: 10.1128/aac.32.5.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McNicol P. J., Albritton W. L., Ronald A. R. Characterization of ampicillin resistance plasmids of Haemophilus ducreyi and Neisseria gonorrhoeae with regard to location of origin of transfer and mobilization by a conjugative plasmid of Haemophilus ducreyi. J Bacteriol. 1983 Oct;156(1):437–440. doi: 10.1128/jb.156.1.437-440.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Morse S. A., Johnson S. R., Biddle J. W., Roberts M. C. High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant. Antimicrob Agents Chemother. 1986 Nov;30(5):664–670. doi: 10.1128/aac.30.5.664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pintado C., Salvador C., Rotger R., Nombela C. Multiresistance plasmid from commensal Neisseria strains. Antimicrob Agents Chemother. 1985 Jan;27(1):120–124. doi: 10.1128/aac.27.1.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Roberts M. C., Hillier S. L., Hale J., Holmes K. K., Kenny G. E. Tetracycline resistance and tetM in pathogenic urogenital bacteria. Antimicrob Agents Chemother. 1986 Nov;30(5):810–812. doi: 10.1128/aac.30.5.810. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Roberts M. C., Kenny G. E. Conjugal transfer of transposon Tn916 from Streptococcus faecalis to Mycoplasma hominis. J Bacteriol. 1987 Aug;169(8):3836–3839. doi: 10.1128/jb.169.8.3836-3839.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Roberts M. C., Kenny G. E. Dissemination of the tetM tetracycline resistance determinant to Ureaplasma urealyticum. Antimicrob Agents Chemother. 1986 Feb;29(2):350–352. doi: 10.1128/aac.29.2.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Roberts M. C., Knapp J. S. Host range of the conjugative 25.2-megadalton tetracycline resistance plasmid from Neisseria gonorrhoeae and related species. Antimicrob Agents Chemother. 1988 Apr;32(4):488–491. doi: 10.1128/aac.32.4.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Roberts M. C., Knapp J. S. Transfer of beta-lactamase plasmids from Neisseria gonorrhoeae to Neisseria meningitidis and commensal Neisseria species by the 25.2-megadalton conjugative plasmid. Antimicrob Agents Chemother. 1988 Sep;32(9):1430–1432. doi: 10.1128/aac.32.9.1430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Roberts M. C., Koutsky L. A., Holmes K. K., LeBlanc D. J., Kenny G. E. Tetracycline-resistant Mycoplasma hominis strains contain streptococcal tetM sequences. Antimicrob Agents Chemother. 1985 Jul;28(1):141–143. doi: 10.1128/aac.28.1.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Roberts M. C., Moncla B. J. Tetracycline resistance and TetM in oral anaerobic bacteria and Neisseria perflava-N. sicca. Antimicrob Agents Chemother. 1988 Aug;32(8):1271–1273. doi: 10.1128/aac.32.8.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Roberts M. C. Plasmid-mediated Tet M in Haemophilus ducreyi. Antimicrob Agents Chemother. 1989 Sep;33(9):1611–1613. doi: 10.1128/aac.33.9.1611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Roberts M., Elwell L. P., Falkow S. Molecular characterization of two beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae. J Bacteriol. 1977 Aug;131(2):557–563. doi: 10.1128/jb.131.2.557-563.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rotger R., García-Valdés E., Trallero E. P. Characterization of a beta-lactamase-specifying plasmid isolated from Eikenella corrodens and its relationship to a commensal Neisseria plasmid. Antimicrob Agents Chemother. 1986 Sep;30(3):508–509. doi: 10.1128/aac.30.3.508. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Rotger R., Rubio F., Nombela C. A multi-resistance plasmid isolated from commensal Neisseria species is closely related to the enterobacterial plasmid RSF1010. J Gen Microbiol. 1986 Sep;132(9):2491–2496. doi: 10.1099/00221287-132-9-2491. [DOI] [PubMed] [Google Scholar]
  25. Senghas E., Jones J. M., Yamamoto M., Gawron-Burke C., Clewell D. B. Genetic organization of the bacterial conjugative transposon Tn916. J Bacteriol. 1988 Jan;170(1):245–249. doi: 10.1128/jb.170.1.245-249.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Zilhao R., Papadopoulou B., Courvalin P. Occurrence of the Campylobacter resistance gene tetO in Enterococcus and Streptococcus spp. Antimicrob Agents Chemother. 1988 Dec;32(12):1793–1796. doi: 10.1128/aac.32.12.1793. [DOI] [PMC free article] [PubMed] [Google Scholar]

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