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. 1990 Mar;34(3):484–486. doi: 10.1128/aac.34.3.484

Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus.

Y Sumita 1, M Fukasawa 1, T Okuda 1
PMCID: PMC171622  PMID: 2334163

Abstract

SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 microgram/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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