Abstract
A patient with an implanted artificial heart, acute, anuric renal failure, and disseminated influenza virus type A infection received intravenous ribavirin. Drug elimination by hemodialysis was measured. Plasma dialysis clearance averaged 93.9 +/- 8.6 ml/min. The maximum amount of ribavirin removed from the body during one period of hemodialysis was 79.1 mg. Ribavirin is not removed in important quantities by hemodialysis.
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- Austin R. K., Trefts P. E., Hintz M., Connor J. D., Kagnoff M. F. Sensitive radioimmunoassay for the broad-spectrum antiviral agent ribavirin. Antimicrob Agents Chemother. 1983 Nov;24(5):696–701. doi: 10.1128/aac.24.5.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Canonico P. G., Kastello M. D., Cosgriff T. M., Donovan J. C., Ross P. E., Spears C. T., Stephen E. L. Hematological and bone marrow effects of ribavirin in rhesus monkeys. Toxicol Appl Pharmacol. 1984 Jun 30;74(2):163–172. doi: 10.1016/0041-008x(84)90139-x. [DOI] [PubMed] [Google Scholar]
- Gilbert B. E., Wilson S. Z., Knight V., Couch R. B., Quarles J. M., Dure L., Hayes N., Willis G. Ribavirin small-particle aerosol treatment of infections caused by influenza virus strains A/Victoria/7/83 (H1N1) and B/Texas/1/84. Antimicrob Agents Chemother. 1985 Mar;27(3):309–313. doi: 10.1128/aac.27.3.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Knight V., McClung H. W., Wilson S. Z., Waters B. K., Quarles J. M., Cameron R. W., Greggs S. E., Zerwas J. M., Couch R. B. Ribavirin small-particle aerosol treatment of influenza. Lancet. 1981 Oct 31;2(8253):945–949. doi: 10.1016/s0140-6736(81)91152-1. [DOI] [PubMed] [Google Scholar]
- Laskin O. L., Longstreth J. A., Hart C. C., Scavuzzo D., Kalman C. M., Connor J. D., Roberts R. B. Ribavirin disposition in high-risk patients for acquired immunodeficiency syndrome. Clin Pharmacol Ther. 1987 May;41(5):546–555. doi: 10.1038/clpt.1987.70. [DOI] [PubMed] [Google Scholar]
- McClung H. W., Knight V., Gilbert B. E., Wilson S. Z., Quarles J. M., Divine G. W. Ribavirin aerosol treatment of influenza B virus infection. JAMA. 1983 May 20;249(19):2671–2674. [PubMed] [Google Scholar]
- McCormick J. B., King I. J., Webb P. A., Scribner C. L., Craven R. B., Johnson K. M., Elliott L. H., Belmont-Williams R. Lassa fever. Effective therapy with ribavirin. N Engl J Med. 1986 Jan 2;314(1):20–26. doi: 10.1056/NEJM198601023140104. [DOI] [PubMed] [Google Scholar]
- Ray C. G., Icenogle T. B., Minnich L. L., Copeland J. G., Grogan T. M. The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. J Infect Dis. 1989 May;159(5):829–836. doi: 10.1093/infdis/159.5.829. [DOI] [PubMed] [Google Scholar]
- Wilson S. Z., Gilbert B. E., Quarles J. M., Knight V., McClung H. W., Moore R. V., Couch R. B. Treatment of influenza A (H1N1) virus infection with ribavirin aerosol. Antimicrob Agents Chemother. 1984 Aug;26(2):200–203. doi: 10.1128/aac.26.2.200. [DOI] [PMC free article] [PubMed] [Google Scholar]