Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1997 Mar;76(3):272–274. doi: 10.1136/adc.76.3.272

Randomised double blind study of hypotonic oral rehydration solution in diarrhoea

T Rautanen 1, S Kurki 1, T Vesikari 1
PMCID: PMC1717093  PMID: 9135272

Abstract

Accepted 19 November 1996


A hypotonic (osmolality 224 mmol/l, sodium 60 mmol/l) oral rehydration solution (ORS) was compared with an isotonic high glucose ORS (osmolality 304 mmol/l, sodium 60 mmol/l) in children with acute diarrhoea in a randomised double blind study. The stool output and hence the mean consumption of ORS for maintenance hydration was less (p = 0.036) in patients receiving hypotonic (69 ml/kg) than isotonic (97 ml/kg) ORS. Hypotonic ORS was more effective in patients with rotavirus positive than with rotavirus negative diarrhoea.



Full Text

The Full Text of this article is available as a PDF (70.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cunha Ferreira R. M., Elliott E. J., Watson A. J., Brennan E., Walker-Smith J. A., Farthing M. J. Dominant role for osmolality in the efficacy of glucose and glycine-containing oral rehydration solutions: studies in a rat model of secretory diarrhoea. Acta Paediatr. 1992 Jan;81(1):46–50. doi: 10.1111/j.1651-2227.1992.tb12077.x. [DOI] [PubMed] [Google Scholar]
  2. Farthing M. J. Disease-related animal models for optimising oral rehydration solution composition. Acta Paediatr Scand Suppl. 1989;364:23–30. doi: 10.1111/j.1651-2227.1989.tb11317.x. [DOI] [PubMed] [Google Scholar]
  3. Farthing M. J. Oral rehydration therapy. Pharmacol Ther. 1994;64(3):477–492. doi: 10.1016/0163-7258(94)90020-5. [DOI] [PubMed] [Google Scholar]
  4. Gore S. M., Fontaine O., Pierce N. F. Impact of rice based oral rehydration solution on stool output and duration of diarrhoea: meta-analysis of 13 clinical trials. BMJ. 1992 Feb 1;304(6822):287–291. doi: 10.1136/bmj.304.6822.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hunt J. B., Thillainayagam A. V., Salim A. F., Carnaby S., Elliott E. J., Farthing M. J. Water and solute absorption from a new hypotonic oral rehydration solution: evaluation in human and animal perfusion models. Gut. 1992 Dec;33(12):1652–1659. doi: 10.1136/gut.33.12.1652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Islam A., Molla A. M., Ahmed M. A., Yameen A., Thara R., Molla A., Issani Z., Hendricks K., Snyder J. D. Is rice based oral rehydration therapy effective in young infants? Arch Dis Child. 1994 Jul;71(1):19–23. doi: 10.1136/adc.71.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mahalanabis D., Faruque A. S., Hoque S. S., Faruque S. M. Hypotonic oral rehydration solution in acute diarrhoea: a controlled clinical trial. Acta Paediatr. 1995 Mar;84(3):289–293. doi: 10.1111/j.1651-2227.1995.tb13630.x. [DOI] [PubMed] [Google Scholar]
  8. Multicentre evaluation of reduced-osmolarity oral rehydration salts solution. International Study Group on Reduced-osmolarity ORS solutions. Lancet. 1995 Feb 4;345(8945):282–285. [PubMed] [Google Scholar]
  9. Rautanen T., el-Radhi S., Vesikari T. Clinical experience with a hypotonic oral rehydration solution in acute diarrhoea. Acta Paediatr. 1993 Jan;82(1):52–54. doi: 10.1111/j.1651-2227.1993.tb12516.x. [DOI] [PubMed] [Google Scholar]
  10. Sandhu B. K., Christobal F. L., Brueton M. J. Optimising oral rehydration solution composition in model systems: studies in normal mammalian small intestine. Acta Paediatr Scand Suppl. 1989;364:17–22. doi: 10.1111/j.1651-2227.1989.tb11316.x. [DOI] [PubMed] [Google Scholar]
  11. Thillainayagam A. V., Carnaby S., Dias J. A., Clark M. L., Farthing M. J. Evidence of a dominant role for low osmolality in the efficacy of cereal based oral rehydration solutions: studies in a model of secretory diarrhoea. Gut. 1993 Jul;34(7):920–925. doi: 10.1136/gut.34.7.920. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Waldor M. K., Mekalanos J. J. Lysogenic conversion by a filamentous phage encoding cholera toxin. Science. 1996 Jun 28;272(5270):1910–1914. doi: 10.1126/science.272.5270.1910. [DOI] [PubMed] [Google Scholar]
  13. da Cunha Ferreira R. M. Optimising oral rehydration solution composition for the children of Europe: clinical trials. Acta Paediatr Scand Suppl. 1989;364:40–50. doi: 10.1111/j.1651-2227.1989.tb11319.x. [DOI] [PubMed] [Google Scholar]
  14. el-Mougi M., Hegazi E., Galal O., el Akkad N., el-Abhar A., Nour N., el-Hadi Emam M., Ahmadi A. R. Controlled clinical trial on the efficacy of rice powder-based oral rehydration solution on the outcome of acute diarrhea in infants. J Pediatr Gastroenterol Nutr. 1988 Jul-Aug;7(4):572–576. doi: 10.1097/00005176-198807000-00016. [DOI] [PubMed] [Google Scholar]
  15. el-Mougi M., el-Akkad N., Hendawi A., Hassan M., Amer A., Fontaine O., Pierce N. F. Is a low-osmolarity ORS solution more efficacious than standard WHO ORS solution? J Pediatr Gastroenterol Nutr. 1994 Jul;19(1):83–86. doi: 10.1097/00005176-199407000-00013. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES