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. 1990 May;34(5):881–883. doi: 10.1128/aac.34.5.881

Multicenter prospective study of treatment of Brucella melitensis brucellosis with doxycycline for 6 weeks plus streptomycin for 2 weeks.

J M Cisneros 1, P Viciana 1, J Colmenero 1, J Pachón 1, C Martinez 1, A Alarcón 1
PMCID: PMC171710  PMID: 2193624

Abstract

The effectiveness of treating human brucellosis caused by Brucella melitensis with a 6-week course of doxcycline plus streptomycin for 2 of those weeks was analyzed by a multicenter prospective study of 139 patients. Subjects with central nervous system involvement, endocarditis, or spondylitis were excluded from the study. All but 5 of the 139 patients completed the full treatment schedule and became afebrile in the first week of therapy. Four patients suffered relapses during the follow-up period. Of the five patients who did not complete the treatment, two left because of adverse secondary effects (1.4%), another two left for noncomplicance with the treatment (1.4%), and the remaining patient was considered a therapeutic failure because his symptoms persisted after the first week of therapy (0.7%). We concluded that the combination of doxycycline and streptomycin is an effective treatment for the types of brucellosis included in our study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ariza J., Bosch J., Gudiol F., Liñares J., Viladrich P. F., Martín R. Relevance of in vitro antimicrobial susceptibility of Brucella melitensis to relapse rate in human brucellosis. Antimicrob Agents Chemother. 1986 Dec;30(6):958–960. doi: 10.1128/aac.30.6.958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ariza J., Gudiol F., Pallarés R., Rufí G., Fernández-Viladrich P. Comparative trial of rifampin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis. Antimicrob Agents Chemother. 1985 Oct;28(4):548–551. doi: 10.1128/aac.28.4.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ariza J. Tratamiento antimicrobiano actual de la brucelosis. Med Clin (Barc) 1983 Dec 10;81(19):870–876. [PubMed] [Google Scholar]
  4. Bertrand A., Jonquet O. Traitement antibiotique de la brucellose. Sem Hop. 1982 Feb 4;58(5):281–283. [PubMed] [Google Scholar]
  5. Bertrand A., Roux J., Janbon F., Jourdan J., Jonquet O. Traitement de la brucellose par la rifampicine. Résultats préliminaires. Nouv Presse Med. 1979 Nov 12;8(44):3635–3639. [PubMed] [Google Scholar]
  6. Colmenero Castillo J. D., Hernandez Marquez S., Reguera Iglesias J. M., Cabrera Franquelo F., Rius Diaz F., Alonso A. Comparative trial of doxycycline plus streptomycin versus doxycycline plus rifampin for the therapy of human brucellosis. Chemotherapy. 1989;35(2):146–152. doi: 10.1159/000238662. [DOI] [PubMed] [Google Scholar]
  7. FARID Z., MIALE A., Jr, OMAR M. S., VAN PEENEN P. F. Antibiotic treatment of acute brucellosis caused by Brucella melitensis. J Trop Med Hyg. 1961 Jul;64:157–163. [PubMed] [Google Scholar]
  8. Feiz J. M., Sabbaghian H., Sohrabi F. A comparative study of therapeutic agents used for treatment of acute brucellosis. Br J Clin Pract. 1973 Nov;27(11):410–413. [PubMed] [Google Scholar]
  9. Fribourg-Blanc A. Diagnostic sérologique de la brucellose par la technique d'immuno-fluorescence. Presse Med. 1970 Jan 31;78(6):271–272. [PubMed] [Google Scholar]
  10. Llorens-Terol J., Busquets R. M. Brucellosis treated with rifampicin. Arch Dis Child. 1980 Jun;55(6):486–488. doi: 10.1136/adc.55.6.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MAGILL G. B., KILLOUGH J. H. Oxytetracycline-streptomycin therapy in brucellosis due to Brucella melitensis. AMA Arch Intern Med. 1953 Feb;91(2):204–211. doi: 10.1001/archinte.1953.00240140064005. [DOI] [PubMed] [Google Scholar]
  12. Morgan W. J., MacKinnon D. J., Lawson J. R., Cullen G. A. The rose bengal plate agglutination test in the diagnosis of brucellosis. Vet Rec. 1969 Dec 6;85(23):636–641. doi: 10.1136/vr.85.23.636. [DOI] [PubMed] [Google Scholar]
  13. Philippon A. M., Plommet M. G., Kazmierczak A., Marly J. L., Nevot P. A. Rifampin in the treatment of experimental brucellosis in mice and guinea pigs. J Infect Dis. 1977 Oct;136(4):481–488. [PubMed] [Google Scholar]
  14. RUIZ CASTANEDA M. Laboratory diagnosis of brucellosis in man. Bull World Health Organ. 1961;24:73–84. [PMC free article] [PubMed] [Google Scholar]
  15. SPINK W. W., BRADLEY G. M. Persistent parasitism in experimental brucellosis: attempts to eliminate brucellae with long-term tetracycline therapy. J Lab Clin Med. 1960 Apr;55:535–547. [PubMed] [Google Scholar]
  16. Santillana López T., Castañeda Alonso E., Fraga Estevez I., Ruíz de Aguiar González A. Brucelosis: consideraciones clínicas y terapéuticas. Revisión de 50 casos. Rev Clin Esp. 1976 Apr 30;141(2):131–137. [PubMed] [Google Scholar]
  17. Vargas V., Pedreira J. D., Clotet B., Juste C., Guardia J., Bacardi R. Tratamiento de la brucelosis agunda con cotrimoxazol, doxiciclina y estreptomicina. Estudio comparativo. Med Clin (Barc) 1980 Dec 15;75(10):418–420. [PubMed] [Google Scholar]

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