Abstract
Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (greater than 50% suppression of lesion size) against L. braziliensis panamensis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- El-On J., Messer G. Leishmania major: antileishmanial activity of methylbenzethonium chloride. Am J Trop Med Hyg. 1986 Nov;35(6):1110–1116. doi: 10.4269/ajtmh.1986.35.1110. [DOI] [PubMed] [Google Scholar]
- Ghosh A. K., Bhattacharyya F. K., Ghosh D. K. Leishmania donovani: amastigote inhibition and mode of action of berberine. Exp Parasitol. 1985 Dec;60(3):404–413. doi: 10.1016/0014-4894(85)90047-5. [DOI] [PubMed] [Google Scholar]
- Ghosh A. K., Rakshit M. M., Ghosh D. K. Effect of berberine chloride on Leishmania donovani. Indian J Med Res. 1983 Sep;78:407–416. [PubMed] [Google Scholar]
- Hanson W. L., Chapman W. L., Jr, Kinnamon K. E. Testing of drugs for antileishmanial activity in golden hamsters infected with Leishmania donovani. Int J Parasitol. 1977 Dec;7(6):443–447. doi: 10.1016/0020-7519(77)90004-2. [DOI] [PubMed] [Google Scholar]
- Vennerstrom J. L., Klayman D. L. Protoberberine alkaloids as antimalarials. J Med Chem. 1988 Jun;31(6):1084–1087. doi: 10.1021/jm00401a006. [DOI] [PubMed] [Google Scholar]